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Forest plot of grade 3–5 endocrine adverse events with subgroup analyses based on ICB subtype. (a) Thyroiditis. (b) Hyperthyroidism. (c) Hypothyroidism. (d) Adrenal insufficiency. (e) Hypophysitis. (f) Type 1 diabetes mellitus. (g) Hyperglycemia.
CI, confidence interval; CTLA-4, T lymphocyte-associated protein 4; ICB, immune checkpoint blockade; PD-1, programmed cell death protein-1; PD-L1, programmed cell death ligand-1.
