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. 2024 May 13;14(8):3029–3042. doi: 10.7150/thno.96092

Figure 5.

Figure 5

Modulation of Cxcl2, Mmp9, and Angpt2 protein expression by targeting CtsC. A Male WT C57BL/6J mice received, in a prophylactic treatment protocol with four AZD7986 administrations (see Figure 3A), either 0.9% NaCl (ctrl), or 0.9% NaCl + AZD7986 (5 mg/kg), or APAP (300 mg/kg), or APAP (300 mg/kg) + AZD7986 (5 mg/kg). Groups not treated with AZD7986 received four administrations of vehicle-AZD7986. After 30 h (protocol III), hepatic protein levels of Cxcl2 were analyzed by ELISA (n = 8 for each group; *p < 0.05, **p < 0.01). B-D Male WT and CtsC-KO C57BL/6J mice received either 0.9% NaCl (ctrl) or APAP (300 mg/kg) (see Figure 2A-C). After 30 h (protocol I), hepatic levels of Cxcl2 (B), Mmp9 (C), and Angpt2 (D) protein were analyzed by ELISA (n = 8 for each group; **p < 0.01, ***p < 0.001). Statistical analysis: A-B, raw data were analyzed by Kruskal-Wallis test with post hoc Dunn's test and are shown as boxplots; C-D, raw data were analyzed by one-way ANOVA with post hoc Bonferroni correction and are shown as means ± SEM. n.s., not statistically significant.