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. 2024 May 19;14(8):3104–3126. doi: 10.7150/thno.96163

Figure 5.

Figure 5

Integrated analyses of lymphocytes, NK cells and ILCs. (A) UMAP plot showing diverse subsets of T cells and ILCs. (B) Bubble heatmap showing expression levels of selected signature genes in T cells and ILCs. Dot size indicates fraction of expressing cells, colored based on average normalized expression levels. (C) Bar chart showing the relative proportion of major T/ILC cell types in different molecular subtypes. (D) Violin plot showing representative naïve, cytotoxic, exhausted and Treg signatures in diverse T/ILC subsets. Dashed red line denotes the median module score. (E) UMAP plot showing three main subsets of NK/ILC cells. (F) Violin plot showing expression levels of selected signature genes in NK/ILC cells. (G) GO enrichment analysis using the top 50 significantly expressed genes of each NK/ILC subset. (H) Kaplan-Meier plot showing better clinical outcome in breast cancer patients with higher composition of ILC3_IL7R subset within the METABRIC cohort. P value is calculated using the log-rank test.