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An overview of the present study. (1) A VBM meta-analysis was conducted to derive an Activation Likelihood Estimation (ALE) map summarizing AD effects on the brain visible in T1-weighted MRI scans. (2) 3D CNNs were trained to classify AD and CN ADNI T1-weighted MRI scans. (3) Three heatmap methods were applied to the CNN models with the highest cross-validation accuracy. (4) The heatmaps were compared with the meta-analysis map.
