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. Author manuscript; available in PMC: 2024 Jun 6.
Published in final edited form as: J Am Chem Soc. 2023 Dec 22;146(1):677–694. doi: 10.1021/jacs.3c10406

Figure 2.

Figure 2.

DNA and RNA constructs selected for NMR measurements. (a) 2D representations of the different d(CpG) and r(CpG) constructs used for NMR measurements in this study. DNA bases are more lightly shaded than RNA ones. Methyl groups for the modified constructs are depicted as small grey circles and indicate their relative position within the duplex. (b) Fits of circular dichroism titrations of NaClO4 into the DNA and RNA constructors shown in (a), with the fraction of the duplex in the Z-conformation on the y-axis and the concentration of NaClO4 (M) on the x-axis. The fraction of Z-DNA and Z-RNA was tracked by following the ellipticity at 266 and 285 nm, respectively, as described in the Methods sections.