Table 2.
Overview of preoperative tests to estimate adequate remnant liver function Adapted from Sparrelid et al[3]
|
Test
|
Agent used
|
FLR volume
|
TL function
|
FLR function
|
Distribution
|
FLR function after
|
Complexity
|
Validated for PHLF
|
| Volumetry | Yes | No | No | No | – | – | ++ | |
| Laboratory scores | No | No1 | No | No | – | – | + | |
| ICG test | Indocyanine green | No | Yes | No | No | – | + | ++ |
| LIMAX | 13C-methacetin | No | Yes | No | No | – | + | + |
| LIMAX+volumetry | 13C-methacetin | Yes | Yes | Yes | No | + | ++ | + |
| ICG+volumetry | Indocyanine green | Yes | Yes | Yes | No | + | ++ | ++ |
| HBS | 99mTc-Mebrofenin | Yes | Yes | Yes | Yes | ++ | ++ | ++ |
| RLE-MRI | Gadoxetic Acid | Yes | Limited2 | Limited2 | Yes | +2 | + | + |
| DCE-MRI | Gadoxetic Acid | Yes | Yes | Yes | Yes | ++ | +++ | – |
1
Only sensitive in low liver function/cirrhosis.
2
Not absolute.
ICG: Indocyanine green; HBS: Hepatobiliary scintigraphy; RLE: Relative liver enhancement; MRI: Magnetic resonance imaging; DCE: Dynamic contrast-enhanced; FLR: Future liver remnant; TL: Total liver; PHLF: Posthepatectomy liver failure; +: Low; ++: Medium; +++: High.