Table I.
Effects of Hippo modulation post-radiation.
| First author(s), year | Cancer type | In vitro/In vivo | Model | IR dose, Gy | Hippo modulation | Result | (Refs.) |
|---|---|---|---|---|---|---|---|
| Moon et al, 2021 | Pancreatic | In vitro | Panc-1 cells | 2, 4 | Catechol treatmenta | Decreased survival fraction | (40) |
| Zhou et al, 2020 | Esophageal | In vitro | Eca109, Kyse150 and TE1 cells | 2, 4, 6, 10 | SiTAZa | Decreased survival fraction Increased DNA damage |
(38) |
| TAZ overexpression via plasmidsb | Increased surviving fraction Reduced DNA damage |
||||||
| Xin et al, 2022 | In vitro | Eca109 and Kyse510 cells | 3, 6, 9 | ShCD155a | Decreased nuclear YAP Decreased proliferation and migration |
(39) | |
| Andrade et al, 2017 | Breast | In vitro | MDA-MB231 and MDA- MB468 cells | 2, 4, 6 | ShYAP1a | Decreased survival fraction | (41) |
| Liang et al, 2022 | In vivo | Xenomorphic 4 (x3 radiation injection of MDA-MB-231 cells in mice | cycles) | YAP overexpressionb | Increased tumour growth | (42) | |
| Zhang et al, 2021 | Glioma | In vitro | U87 and U251 cells | 4, 6, 8, 10 | YAP overexpression via vectorsb | Increased surviving (108) fraction Increased DNA repair |
|
| In vivo | Xenomorphic injection of U251 and GBM1 cells in mice | 10 | YAP overexpression via vectorsb | Decreased tumour size Decreased survival |
|||
| Zeng et al, 2020 | Non-small cell lung cancer | In vitro | A549 and H1299 cells | 2, 4, 6, 8 | SiCDK5 (Hippo modulator)a | Decreased DNA damage | (12) |
| In vivo | Xenomorphic injection of H1299 cells in mice | 10 | ShCDK5 (Hippo modulator)a | Decreased size of tumour Decreased DNA damage |
|||
| Li et al, 2022 | In vitro | A549, H1299 and H460 cells | 2, 4, 6, 8 | p130cas (YAP modulator) overexpression via vectorsb ShP130cas (YAP modulator)a | Increased survival fraction Decreased DNA damage Increased DNA damage Increased tumour size |
(44) | |
| In vivo | Xenomorphic injection of H1299 cells in mice | 8 (x3) | p130cas (YAP modulator) overexpression via vectorsb |
The Hippo pathway modulates the aoverexpression or binhibition of effector proteins and has radioresistance properties post-radiation. IR, ionizing radiation; YAP, yes-associated protein 1; TAZ, transcriptional coactivator with a PDZ-binding domain; p130cas, breast cancer anti-estrogen resistance protein 1; si; short-interfering RNA; sh, short hairpin RNA.