| Incident hypertension (≥140/90 mmHg) | |||||
|---|---|---|---|---|---|
| Range | Events | Crude | Age and Sex | Multivariable** | |
| Body mass index < 25 kg/m2 | |||||
| TSH | mIU/L | ||||
| Continuous* | - | 175 (5.9) | 1.00 (0.99-1.00) | 0.99 (0.99-1.00) | 1.00 (0.99-1.00) |
| Q1 | 0.01-1.29 | 48 (8) | 1.02 (1.00-1.05) | 1.03 (1.00-1.05) | 1.02 (0.99-1.04) |
| Q2 | 1.30-1.76 | 32 (5.5) | 1.00 (0.98-1.03) | 1.00 (0.98-1.03) | 1.00 (0.98-1.02) |
| Q3 | 1.77-2.27 | 32 (5.4) | reference | reference | reference |
| Q4 | 2.28-3.06 | 29 (4.9) | 1.00 (0.97-1.02) | 0.99 (0.97-1.02) | 0.99 (0.97-1.01) |
| Q5 | 3.07-14.9 | 34 (5.8) | 1.00 (0.98-1.03) | 1.00 (0.97-1.02) | 1.00 (0.98-1.03) |
| FT4 | ng/dL | ||||
| Continuous* | - | 175 (5.9) | 1.00 (0.9 -1.05) | 0.98 (0.93-1.04) | 0.98 (0.93-1.04) |
| Q1 | 0.49-1.07 | 38 (6.4) | 0.99 (0.97-1.02) | 0.99 (0.97-1.02) | 0.99 (0.96-1.02) |
| Q2 | 1.08-1.15 | 25 (4.3) | 0.97 (0.95-1.00) | 0.98 (0.95-1.00) | 0.97 (0.95-1.00) |
| Q3 | 1.16-1.23 | 45 (7) | reference | reference | reference |
| Q4 | 1.24-1.32 | 38 (7) | 1.00 (0.97-1.03) | 1.00 (0.97-1.02) | 1.00 (0.97-1.02) |
| Q5 | 1.33-2.02 | 27 (4.7) | 0.98 (0.95-1.00) | 0.97 (0.95-1.00) | 0.97 (0.95-0.99) |
| FT3 | ng/dL | ||||
| Continuous* | - | 175 (5.9) | 1.24 (0.98-1.56) | 1.14 (0.89-1.45) | 1.05 (0.82-1.34) |
| Q1 | 0.18-0.28 | 37 (5.5) | 0.99 (0.97-1.02) | 1.00 (0.98-1.02) | 1.00 (0.97-1.02) |
| Q2 | 0.29-0.30 | 25 (4.2) | 0.98 (0.96-1.00) | 0.99 (0.96-1.01) | 0.99 (0.96-1.01) |
| Q3 | 0.31-0.32 | 37 (6.2) | reference | reference | reference |
| Q4 | 0.33-0.34 | 26 (5.1) | 0.99 (0.96-1.01) | 0.99 (0.96-1.02) | 0.99 (0.96-1.01) |
| Q5 | 0.35-0.71 | 48 (8.7) | 1.02 (0.99-1.05) | 1.02 (0.99-1.05) | 1.01 (0.98-1.04) |
| FT3:FT4 | |||||
| Continuous* | 175 (5.9) | 1.24 (0.97-1.59) | 1.18 (0.93-1.50) | 1.11 (0.87-1.41) | |
| Q1 | 0.142-0.233 | 32 (5.5) | 1.01 (0.98-1.03) | 1.01 (0.98-1.03) | 1.01 (0.99-1.03) |
| Q2 | 0.234-0.252 | 34 (5.8) | 1.01 (0.99-1.03) | 1.01 (0.99-1.04) | 1.01 (0.99-1.04) |
| Q3 | 0.253-0.271 | 28 (4.8) | reference | reference | reference |
| Q4 | 0.272-0.294 | 38 (6.5) | 1.02 (0.99-1.04) | 1.01 (0.99-1.04) | 1.01 (0.99-1.04) |
| Q5 | 0.295-0.518 | 41 (7) | 1.02 (1.00-1.05) | 1.02 (0.99-1.05) | 1.01 (0.99-1.04) |
| Body mass index ≥ 25 kg/m2 | |||||
| TSH | mIU/L | ||||
| Continuous* | - | 319 (8.9) | 1.00 (0.99-1.01) | 1.00 (0.99-1.01) | 1.00 (0.99-1.01) |
| Q1 | 0.01-1.30 | 69 (9.6) | 1.01 (0.99-1.04) | 1.01 (0.99-1.04) | 1.01 (0.98-1.03) |
| Q2 | 1.31-1.72 | 74 (10.3) | 1.02 (0.99-1.05) | 1.02 (0.99-1.05) | 1.02 (0.99-1.05) |
| Q3 | 1.73-2.27 | 59 (8.3) | reference | reference | reference |
| Q4 | 2.28-3.10 | 57 (8.1) | 1.00 (0.97-1.02) | 0.99 (0.97-1.02) | 1.00 (0.97-1.02) |
| Q5 | 3.11-18.92 | 60 (8.5) | 1.00 (0.98-1.03) | 0.99 (0.97-1.02) | 1.00 (0.97-1.03) |
| FT4 | ng/dL | ng/dL | |||
| Continuous* | - | 319 (8.9) | 1.01 (0.95-1.07) | 0.99 (0.93-1.05) | 0.99 (0.93-1.05) |
| Q1 | 0.18-1.04 | 69 (9) | 1.02 (0.99-1.05) | 1.02 (0.99-1.04) | 1.02 (0.99-1.04) |
| Q2 | 1.05-1.12 | 61 (9.3) | 1.02 (1.00-1.05) | 1.02 (0.99-1.05) | 1.03 (1.00-1.06) |
| Q3 | 1.13-1.20 | 51 (6.9) | reference | reference | reference |
| Q4 | 1.21-1.30 | 68 (9.4) | 1.02 (1.00-1.05) | 1.02 (0.99-1.04) | 1.02 (1.00-1.05) |
| Q5 | 1.31-1.93 | 68 (10.4) | 1.03 (1.01-1.06) | 1.03 (1.00-1.05) | 1.03 (1.00-1.05) |
| FT3 | ng/dL | ||||
| Continuous* | - | 319 (8.9) | 1.13 (0.91-1.41) | 1.06 (0.84-1.35) | 1.05 (0.82-1.33) |
| Q1 | 0.18-0.29 | 69 (7.1) | 0.98 (0.96-1.01) | 0.99 (0.97-1.02) | 0.99 (0.97-1.02) |
| Q2 | 0.30-0.31 | 83 (10.9) | 1.02 (0.99-1.05) | 1.03 (1.00-1.05) | 1.02 (1.00-1.05) |
| Q3 | 0.32-0.33 | 63 (8.8) | reference | reference | reference |
| Q4 | 0.34-0.35 | 50 (9.2) | 1.00 (0.98-1.03) | 1.01 (0.98-1.04) | 1.01 (0.98-1.04) |
| Q5 | 0.36-0.51 | 52 (9.4) | 1.01 (0.98-1.04) | 1.01 (0.98-1.04) | 1.00 (0.97-1.03) |
| FT3:FT4 | |||||
| Continuous* | 319 (8.9) | 1.10 (0.89-1.35) | 1.10 (0.89-1.35) | 1.06 (0.86-1.31) | |
| Q1 | 0.129-0.241 | 58 (8.2) | 1.00 (0.97-1.02) | 0.99 (0.97-1.02) | 0.99 (0.96-1.02) |
| Q2 | 0.242-0.263 | 74 (10.2) | 1.02 (0.99-1.04) | 1.01 (0.99-1.04) | 1.02 (0.99-1.05) |
| Q3 | 0.264-0.282 | 59 (8.5) | reference | reference | reference |
| Q4 | 0.283-0.307 | 58 (8.2) | 1.00 (0.97-1.02) | 1.00 (0.97-1.02) | 1.00 (0.97-1.02) |
| Q5 | 0.308-1.000 | 68 (9.6) | 1.01 (0.98-1.04) | 1.00 (0.98-1.03) | 1.00 (0.97-1.03) |
*
Continuous variables.
**
Adjustment by age, sex, race, education level, smoking and alcohol consumption, and physical activity. Abbreviations: DBP, diastolic blood pressure; FT3:FT4, free T3 to free T4 (conversion) ratio; Q, quintile(s); SBP, systolic blood pressure.