Current clinical status of patients with SJIA-LD. (A) Distribution of PGALD scores at last follow-up for patients with SJIA-LD is shown. (B) Correlation between PGALD score at last follow-up and peak serum IL-18 level is shown. (C) Change in clinical status from LD diagnosis to last follow-up in four cardinal clinical domains (chi-square, P = 0.001) is shown. (D) Hierarchical clustering of patterns of clinical change for patients with SJIA-LD is shown. IL-18, interleukin-18; LD, lung disease; PGALD, Physician Global Assessment of Lung Disease; SJIA, systemic juvenile idiopathic arthritis; SLD, SJIA Lung Disease.