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. 2024 May 6;27(6):1125–1136. doi: 10.1038/s41593-024-01634-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, SAβGal colorimetric assay (top, blue) and pS6 immunostaining (bottom, red) on Depdc5^WT and Depdc5^cKO animals from 3 weeks to 10 weeks of age and quantification of the density of SAβGal⁺ and pS6⁺ cells per mm² in 10-week-old Depdc5^WT (n = 4) and Depdc5^cKO (n = 4) mice. Cc, corpus callosum; L.1–3, cortical layers 1 to 3; L.4, cortical layer 4; L.5–6, cortical layers 5 and 6. b, SAβGal colorimetric assay (blue) and immunohistochemistry against neural cellular markers (DAB) on Depdc5^cKO animals at 10 weeks of age. Quantification of the percentage of SAβGal⁺ cells positive for Gfap, Olig2 or NeuN in n = 6 samples of 10-week-old Depdc5^cKO mice (two slices from rostral and caudal regions per n = 3 animals). c, SAβGal colorimetric assay (blue) and immunohistochemistry against cellular senescence markers (DAB) on Depdc5^WT and Depdc5^cKO animals at 10 weeks of age. Quantification of the percentage of SAβGal⁺ cells positive for p21 and negative for nuclear Hmgb1 and LaminB1 in n = 6 samples of 10-week-old Depdc5^cKO mice (two slices from rostral and caudal regions per n = 3 animals). Scatter dot plots are presented as mean ± s.e.m. nb, number of.

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