Table 1.

In vitro activity of KH9, KH16, and KH29 against the indicated HDACs.

compound	structure	HDAC1 IC50 µM	HDAC2 IC50 µM	HDAC3 IC50 µM	HDAC6 IC50 -μM	HDAC8 IC50 µM	HDAC11 IC50 μM
KH9		0.0089± 0.0005	0.022±0.001	0.019±0.001	0.14±0.01	0.11±0.01	1.5±0.1
KH16		0.013±0.001	0.034±0.001	0.0060 ± 0.0001	0.46±0.03	0.53±0.03	0.87±0.08
KH29		0.0094± 0.0005	0.026±0.001	0.020±0.001	0.025±0.001	0.049±0.002	1.0±0.1
SAHA		0.101±0.007	0.43±0.009	0.21±0.01	0.013±0.001	0.42±0.08	n.d.