Table 1.

Incidence and severity of hepatic histopathological lesions in the experimental groups.

Group ⁄ lesion	Incidence and severity of histopathological lesions
	control				TQ				Diabetic				Diabetic + TQ
	−	+	+  +	+  +  +	−	+	+  +	+  +  +	−	+	+  +	+  +  +	−	+	+  +	+  +  +
Congestion of hepatic vasculature	6	2	0	0	7	1	0	0	0	1	2	5	5	3	0	0
Hepatic hydropic degeneration	7	1	0	0	7	1	0	0	0	1	3	4	6	2	0	0
hepatocellular necrosis	8	0	0	0	8	0	0	0	0	2	3	3	7	1	0	0
Mononuclear cell infiltrations in the portal area	8	0	0	0	8	0	0	0	1	1	3	3	7	1	0	0

Number of animals with lesions per total examined (8 rats per group). TQ Thymoquinone.

Severity of lesions was graded by estimating the percentage area affected in the entire section. Lesion scoring: (−) absence of the lesion = 0%, ( +) mild = 5–25%, (+ +) moderate = 26–50% and (+ + +) severe ≥ 50% of the examined tissue sections.