Table 1.
Mean (standard deviation) area under the curve of plasma amino acid concentrations according to mesna dosing
| 400 mg | 800 mg | 1200 mg | 1600 mg | β (95% CI) |
P trend | |
|---|---|---|---|---|---|---|
| Amino acid, µmol×h/L | ||||||
| Alanine | 4530 (603) | 4000 (794) | 4520 (673) | 4500 (493) |
33.2 (-207, 274) |
0.78 |
| Arginine | 1130 (172) | 1050 (158) | 1080 (70.7) | 1140 (146) |
5.45 (-46.4, 57.3) |
0.83 |
| Asparagine | 445 (59.6) | 429 (84.9) | 530 (61.8) | 452 (97.5) |
12.4 (-17.7, 42.5) |
0.40 |
| Aspartate | 56.7 (28.9) | 43.8 (11.6) | 50.1 (8.1) | 51.4 (8.44) |
-1.20 (-7.5, 5.09) |
0.70 |
| Glutamate | 758 (274) | 563 (172) | 641 (214) | 745 (123) |
0.07 (-78.4, 78.5) |
1.00 |
| Glutamine | 6800 (874) | 6700 (418) | 7320 (446) | 7160 (638) |
165 (-65.1, 396) |
0.15 |
| Glycine | 2610 (411) | 2750 (580) | 2650 (541) | 2540 (556) |
-28.6 (-212, 155) |
0.75 |
| Histidine | 1050 (94) | 1030 (90.9) | 1080 (53.9) | 1040 (63.8) |
1.64 (-26.5, 29.8) |
0.91 |
| Isoleucine | 924 (120) | 1030 (126) | 921 (119) | 1100 (162) |
42.5 (-8.44, 93.4) |
0.098 |
| Leucine | 1660 (198) | 1840 (290) | 1650 (132) | 1870 (191) |
42.9 (-37.2, 123) |
0.28 |
| Lysine | 2080 (156) | 2090 (171) | 2120 (169) | 2300 (384) |
66.5 (-17.7, 151) |
0.12 |
| Ornithine | 876 (134) | 798 (119) | 837 (146) | 841 (73.3) |
-8.05 (-51.7, 35.6) |
0.71 |
| Phenylalanine | 742 (115) | 747 (135) | 752 (70.9) | 824 (47.9) |
24.5 (-10.8, 59.8) |
0.16 |
| Proline | 2190 (601) | 2150 (567) | 2990 (1080) | 2480 (483) |
173 (-97, 443) |
0.20 |
| Serine | 1120 (114) | 1220 (183) | 1230 (253) | 1160 (248) |
16 (-56.8, 88.9) |
0.65 |
| Taurine | 700 (265) | 737 (57.5) | 611 (59.8) | 725 (113) |
-5.13 (-62.9, 52.6) |
0.86 |
| Threonine | 1490 (157) | 1520 (207) | 1590 (169) | 1500 (302) |
11.7 (-64.2, 87.7) |
0.75 |
| Tryptophan | 301 (64.8) | 315 (50.8) | 324 (44.1) | 350 (33.6) |
15.6 (-2.1, 33.2) |
0.081 |
| Tyrosine | 897 (160) | 845 (145) | 808 (117) | 927 (127) |
3.71 (-47.8, 55.3) |
0.88 |
| Valine | 3230 (265) | 3470 (335) | 3390 (233) | 3620 (200) |
110 (14.6, 205) |
0.026 |
| 3-methyl-histidine | 151 (71.2) | 104 (73.6) | 141 (72.8) | 120 (43) |
-6.07 (-31.6, 19.4) |
0.63 |