Table 2.

Summary of key model development steps

Model	Description	OFV
Base model
1	One-compartment model with first-order absorption (including lag time) and combined Michaelis-Menten type nonlinear renal and linear nonrenal elimination	6401.44
Covariate model for effects of co-treatment
2	Base model with separate estimates of apparent bioavailability for reference and test periods	6394.05
3	Model 2 with additional separate estimates for apparent Ka for reference and test periods	6384.89
Final model with demographic and physiological covariates
4	Final model with AGFR as a covariate on Vmax	6372.69

OFV objective function value, K_a first-order absorption rate constant, AGFR absolute estimated glomerular filtration rate