Table 2. Criteria for inclusion and exclusion when recruiting subjects.

Criteria	Terms
Inclusion criteria	• Healthy female aged 35–60 yrs
	• Diagnosed by dermatologists with wrinkle(s) in the Crow’s-feet area, with global photo-damage score between 2 and 6
	• Subjects who calculate with Corneometer reading of less than 60 A.U.
	• Informed of the purpose and the protocol of the study and signed a written informed-consent form
	• Co-operative and available during the study period
Exclusion criteria	• History of allergies to cosmetics, pharmaceutical products, or foods containing ingredients included in the test formulation
	• Diagnosis of any systemic illness that may be aggravated by participation in the study
	• Use of oral retinoids or oral steroids in the 6 mon prior to initiation of the study
	• Use of topical retinoids, anti-wrinkle cosmetic products including retinol and/or AHA, or moisture-rich cosmetic products within the 6 mon prior to initiation of the study
	• Skincare therapy using lasers or peeling within the 6 mon prior to initiation of the study
	• Current participation in another clinical test, or participation in any type of wrinkle study within the 6 mon prior to initiation of the study
	• Abnormal liver function or abnormal renal function
	• Current smoking habit or history of smoking within the past 1 yr
	• Excessive alcohol intake
	• Women who had undergone, or planned to undergo, pregnancy or breastfeeding
	• Blood pressure > 140/90 mmHg or hypertension with intake of a diuretic
	• Problems with overall findings in blood-test results as determined by a specialist
	• History of asthma or allergic disease
	• History of depression, schizophrenia, alcoholism, drug addiction, or mental illness
	• Current or previous intake of contraceptives, female hormones, obesity drugs, absorption inhibitors, antidepressants, or appetite suppressants
	• Any condition judged by the investigator to be unsuitable for participation in the study

A.U., arbitrary units; AHA, alpha hydroxy acid.