Table 6. Skin elasticity parameters.

Parameters		CTP20 group		Placebo group		CTP20/Placebo
		Mean ± SD	P-valuea	Mean ± SD	P-valuea	P-valuea
Skin Elasticity by R2 (Gross elasticity, A.U.)
	Baseline	0.693 ± 0.055		0.694 ± 0.057
	At 6 weeks	0.710 ± 0.054	< 0.001***	0.694 ± 0.052	0.855	< 0.001***
	At 12 weeks	0.726 ± 0.048	< 0.001***	0.693 ± 0.053	0.827	< 0.001***
Skin Elasticity by R5 (Net elasticity, A.U.)
	Baseline	0.596 ± 0.078		0.590 ± 0.076
	At 6 weeks	0.604 ± 0.080	0.002**	0.586 ± 0.073	0.129	< 0.001***
	At 12 weeks	0.627 ± 0.080	< 0.001***	0.585 ± 0.072	0.067	< 0.001***
Skin Elasticity by R7 (Biological elasticity, A.U.)
	Baseline	0.457 ± 0.063		0.452 ± 0.065
	At 6 weeks	0.471 ± 0.066	< 0.001***	0.453 ± 0.064	0.665	< 0.001***
	At 12 weeks	0.484 ± 0.062	< 0.001***	0.452 ± 0.062	0.862	< 0.001***

Hydrolyzed fish skin collagen (Collagen-Tripep20™, Tripep20) was prepared from Pangasius hypophthalmus fish skin by collagenase digestion. Liquid collagen (1,000 mg Tripep20) or placebo in a 50 mL bottle was administered orally to subjects as a daily drink. The skin elasticity parameters were measured using a Cutometer MPA580 device.

^aP-value for repeated measures analysis of variance with a contrast test, compared to the baseline.

^**P < 0.01, ^***P < 0.001 (repeated measures analysis of variance with contrast test).