Table 1.
Crude incidence rate for all ocular melanoma, three major anatomical sites with 1000+ cases and melanoma in other sites combined diagnosed by age, sex, race and ethnicity, diagnosis year, and laterality in the Surveillance, Epidemiology, and End Results Programme between 2000 and 2019.
| Total casesa | Choroid | Ciliary body/iris | Conjunctiva | Other sitesb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | IR (95% CI) | Cases | IR (95% CI) | Cases | IR (95% CI) | Cases | IR (95% CI) | Cases | IR (95% CI) | |
| All | 18,089 | 6.17 (6.08, 6.26) | 13,812 | 4.71 (4.63, 4.79) | 2013 | 0.69 (0.66, 0.72) | 1079 | 0.37 (0.35, 0.39) | 1185 | 0.40 (0.38, 0.43) |
| Age (years) | ||||||||||
| <50 | 3393 | 1.66 (1.60, 1.72) | 2528 | 1.24 (1.19, 1.29) | 457 | 0.22 (0.20, 0.24) | 215 | 0.11 (0.09, 0.12) | 193 | 0.09 (0.08, 0.11) |
| 50–64 | 6199 | 11.9 (11.7, 12.3) | 4866 | 9.41 (9.15, 9.68) | 663 | 1.28 (1.19, 1.38) | 292 | 0.56 (0.50, 0.63) | 378 | 0.73 (0.66, 0.81) |
| 65+ | 8497 | 22.9 (22.4, 23.4) | 6418 | 17.3 (16.9, 17.7) | 893 | 2.41 (2.26, 2.58) | 572 | 1.55 (1.42, 1.68) | 614 | 1.66 (1.53, 1.80) |
| Sex | ||||||||||
| Men | 9370 | 6.49 (6.36, 6.62) | 7192 | 4.98 (4.87, 5.10) | 1024 | 0.71 (0.67, 0.75) | 553 | 0.38 (0.35, 0.42) | 601 | 0.42 (0.38, 0.45) |
| Women | 8719 | 5.86 (5.74, 5.98) | 6620 | 4.45 (4.34, 4.56) | 989 | 0.66 (0.62, 0.71) | 526 | 0.35 (0.32, 0.38) | 584 | 0.39 (0.36, 0.43) |
| Race and ethnicity | ||||||||||
| Non-Hispanic White | 16,645 | 10.1 (9.91, 10.2) | 12,801 | 7.74 (7.60, 7.87) | 1868 | 1.13 (1.08, 1.18) | 908 | 0.55 (0.51, 0.59) | 1068 | 0.65 (0.61, 0.69) |
| Hispanic White | 989 | 1.61 (1.51, 1.71) | 705 | 1.15 (1.06, 1.23) | 107 | 0.17 (0.14, 0.21) | 104 | 0.17 (0.14, 0.20) | 73 | 0.12 (0.09, 0.15) |
| Black | 185 | 0.49 (0.42, 0.56) | 127 | 0.33 (0.28, 0.40) | <25 | ^ | 27 | 0.07 (0.05, 0.10) | <25 | ^ |
| Asian/Pacific Islander | 227 | 0.92 (0.81, 1.05) | 149 | 0.61 (0.51, 0.71) | <25 | ^ | 31 | 0.13 (0.09, 0.18) | 26 | 0.11 (0.07, 0.16) |
| American Indian | 43 | 1.20 (0.87, 1.62) | 30 | 0.84 (0.56, 1.19) | <25 | ^ | <25 | ^ | <25 | ^ |
| Year of diagnosis | ||||||||||
| 2000–03 | 3236 | 5.91 (5.71, 6.12) | 2364 | 4.32 (4.14, 4.49) | 375 | 0.68 (0.62, 0.76) | 189 | 0.35 (0.30, 0.40) | 308 | 0.56 (0.50, 0.63) |
| 2004–07 | 3610 | 6.38 (6.17, 6.59) | 2667 | 4.71 (4.53, 4.89) | 399 | 0.70 (0.64, 0.78) | 245 | 0.43 (0.38, 0.49) | 299 | 0.53 (0.47, 0.59) |
| 2008–11 | 3415 | 5.81 (5.61, 6.01) | 2552 | 4.34 (4.17, 4.51) | 390 | 0.66 (0.60, 0.73) | 225 | 0.38 (0.33, 0.44) | 248 | 0.42 (0.37, 0.48) |
| 2012–15 | 3900 | 6.42 (6.22, 6.62) | 3087 | 5.08 (4.90, 5.26) | 400 | 0.66 (0.60, 0.73) | 218 | 0.36 (0.31, 0.41) | 195 | 0.32 (0.28, 0.37) |
| 2016–19 | 3928 | 6.31 (6.11, 6.51) | 3142 | 5.04 (4.87, 5.22) | 449 | 0.72 (0.66, 0.79) | 202 | 0.32 (0.28, 0.37) | 135 | 0.22 (0.18, 0.36) |
| Laterality | ||||||||||
| Left-sided | 8863 | 3.02 (2.96, 3.09) | 6787 | 2.31 (2.26, 2.37) | 1019 | 0.35 (0.33, 0.37) | 529 | 0.18 (0.17, 0.2) | 528 | 0.18 (0.17, 0.20) |
| Right-sided | 8994 | 3.07 (3.00, 3.13) | 6919 | 2.36 (2.30, 2.42) | 970 | 0.33 (0.31, 0.35) | 536 | 0.18 (0.17, 0.2) | 569 | 0.19 (0.18, 0.21) |
| Othersc | 232 | 0.08 (0.07, 0.09) | 106 | 0.04 (0.03, 0.04) | <25 | ^ | <25 | ^ | 88 | 0.03 (0.02, 0.04) |
^, IR and IRR not calculated for fewer than 25 cases.
IR crude incidence rate (per 1,000,000 person-years), CI confidence interval.
aTotal ocular melanoma included anatomical sites of choroid, ciliary body/iris, conjunctiva, eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland, which ordered by number of cases.
bMelanoma in other sites combined included anatomical sites of eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland.
cOthers included not a paired site; only one side or side unspecified; bilateral, single primary; paired site: midline tumour; paired site, but no information concerning laterality.