Table 2.
Incidence rate ratio of quartile of ambient ultraviolet radiation (UVR) for ocular melanoma, three major anatomical sites with 1000+ cases and melanoma in other sites combined in the surveillance, epidemiology, and end results programme between 2000 and 2019.
| Total populationa | Non-Hispanic Whited | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile of ambient UVR | Number of cases | Adjusted IRRb | 95% CI | p for trendc | Number of cases | Adjusted IRRb | 95% CI | p for trendc | |
| Total casese | Q1 | 5816 | ref. | 0.07 | 5517 | ref. | 0.06 | ||
| Q2 | 5168 | 1.09 | 1.05, 1.14 | 4879 | 1.09 | 1.03, 1.13 | |||
| Q3 | 3559 | 0.98 | 0.93, 1.03 | 3168 | 0.99 | 0.99, 1.09 | |||
| Q4 | 3546 | 0.98 | 0.94, 1.03 | 3081 | 0.98 | 0.93, 1.02 | |||
| Anatomical sites | |||||||||
| Choroid | Q1 | 4580 | ref. | <0.0001 | 4361 | ref. | <0.0001 | ||
| Q2 | 4013 | 1.07 | 1.02, 1.11 | 3808 | 1.07 | 0.98, 1.08 | |||
| Q3 | 2732 | 0.94 | 0.89, 0.99 | 2452 | 0.95 | 0.92, 1.02 | |||
| Q4 | 2487 | 0.86 | 0.82, 0.91 | 2180 | 0.85 | 0.80, 0.90 | |||
| Ciliary body/iris | Q1 | 538 | ref. | <0.0001 | 512 | ref. | <0.0001 | ||
| Q2 | 587 | 1.39 | 1.23, 1.56 | 557 | 1.39 | 1.24, 1.64 | |||
| Q3 | 382 | 1.19 | 1.02, 1.37 | 347 | 1.21 | 1.33, 1.81 | |||
| Q4 | 506 | 1.63 | 1.43, 1.87 | 452 | 1.66 | 1.46, 1.95 | |||
| Conjunctiva | Q1 | 346 | ref. | 0.81 | 315 | ref. | 0.68 | ||
| Q2 | 289 | 1.02 | 0.87, 1.20 | 254 | 1.00 | 0.85, 1.19 | |||
| Q3 | 225 | 0.97 | 0.80, 1.18 | 175 | 0.97 | 0.78, 1.19 | |||
| Q4 | 219 | 0.99 | 0.82, 1.19 | 164 | 0.97 | 0.79, 1.19 | |||
| Other sitesf | Q1 | 352 | ref. | <0.0001 | 329 | ref. | <0.0001 | ||
| Q2 | 279 | 1.06 | 0.90, 1.24 | 260 | 1.08 | 0.92, 1.28 | |||
| Q3 | 220 | 1.17 | 0.96, 1.42 | 194 | 1.24 | 1.01, 1.52 | |||
| Q4 | 334 | 1.66 | 1.40, 1.97 | 285 | 1.69 | 1.41, 2.03 | |||
Cutoffs for ambient UVR quartile: 17.8–<26.4 (referent), 26.5–< 40.1, 40.1–<45.0 and 45.0–76.0 mW/m2.
aTotal populations by quartiles UVR were 2427,929,673, 2049,231,696, 2160,918,462 and 2158,328,571, respectively.
bAdjusted for sex, age at diagnosis (<50, 50–64, 65+), race and ethnicity (non-Hispanic White, others [Hispanic White, Black, Asian Pacific American, American Indian]), year of diagnosis and registry’s population size that was categorised into quartiles using census-based population size to create four roughly equal categories (Q1: Iowa, Utah, Seattle (Puget Sound) Registry, Atlanta (Metropolitan) Registry, Rural and Greater Georgia Registries, San Francisco-Oakland SMSA Registry, San Jose-Monterey Registry, Los Angeles Registry, and Hawaii; Q2: Louisiana, Illinois, and Greater CA Registry; Q3: New Mexico, New York, Connecticut, and New Jersey; Q4: Texas, Idaho, Massachusetts, and Kentucky).
cTrend P values for solar UVR were based on trend tests using ordinal UVR quartiles (1 through 4) with bold indicating significant after Bonferroni correction (10 tests).
dPopulations of non-Hispanic White individuals by quartiles UVR were 1668,263,682, 1375,566,774, 964,597,881, 955,688,856, respectively.
eTotal cases included anatomical sites of choroid, ciliary body/iris, conjunctiva, eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland, which ordered by number of cases.
fMelanoma in other sites combined included anatomical sites of eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland.