Table 3.
Incidence rate ratio of continuous UVR (per 10 mW/m2) for ocular melanoma, three major anatomical sites with 1000+ cases and melanoma in other sites combined by age, sex, race and ethnicity, and laterality in the Surveillance, Epidemiology, and End Results Programme between 2000 and 2019.
| Total casesa | Choroid | Ciliary body/iris | Conjunctiva | Other sitesc | |
|---|---|---|---|---|---|
| IRRb (95% CI) | IRRb (95% CI) | IRRb (95% CI) | IRRb (95% CI) | IRRb (95% CI) | |
| Age (years) | |||||
| <50 | 0.99 (0.95, 1.03) | 0.95 (0.91, 1.00) | 1.17 (1.05, 1.30) | 1.05 (0.90, 1.23) | 1.04 (0.89, 1.22) |
| 50–64 | 0.96 (0.94, 0.99) | 0.92 (0.89, 0.95) | 1.14 (1.05, 1.24) | 1.02 (0.89, 1.15) | 1.21 (1.09, 1.35) |
| 65+ | 0.98 (0.95, 1.00) | 0.93 (0.91, 0.96) | 1.15 (1.07, 1.24) | 0.99 (0.90, 1.08) | 1.24 (1.14, 1.35) |
| Sex | |||||
| Men | 0.97 (0.95, 0.99) | 0.93 (0.90, 0.95) | 1.16 (1.08, 1.24) | 0.99 (0.91, 1.09) | 1.20 (1.10, 1.31) |
| Women | 0.98 (0.96, 1.00) | 0.93 (0.91, 0.96) | 1.14 (1.07, 1.23) | 1.02 (0.92, 1.12) | 1.20 (1.10, 1.31) |
| Race and ethnicity | |||||
| Non-Hispanic White | 0.97 (0.96, 0.99) | 0.93 (0.91, 0.95) | 1.16 (1.10, 1.22) | 0.99 (0.92, 1.07) | 1.20 (1.12, 1.28) |
| Hispanic White | 0.88 (0.81, 0.94) | 0.85 (0.78, 0.93) | 0.95 (0.76, 1.20) | 0.92 (0.73, 1.16) | 1.02 (0.76, 1.36) |
| Black | 1.06 (0.87, 1.30) | 1.14 (0.89, 1.45) | ^ | 0.93 (0.54, 1.59) | ^ |
| Asian /Pacific Islander | 1.00 (0.87, 1.15) | 0.97 (0.81, 1.14) | ^ | 1.00 (0.70, 1.42) | 1.46 (1.01, 2.11) |
| American Indian | 0.71 (0.53, 0.97) | 0.61 (0.42, 0.88) | ^ | ^ | ^ |
| Laterality | |||||
| Left-sided | 0.98 (0.96, 1.00) | 0.94 (0.91, 0.96) | 1.14 (1.07, 1.22) | 0.99 (0.90, 1.09) | 1.21 (1.10, 1.33) |
| Right-sided | 0.97 (0.95, 0.99) | 0.93 (0.91, 0.95) | 1.15 (1.07, 1.23) | 1.04 (0.94, 1.14) | 1.15 (1.05, 1.25) |
| Othersd | 1.01 (0.87, 1.16) | 0.67 (0.53, 0.83) | ^ | ^ | 1.52 (1.21, 1.91) |
^, IR and IRR not calculated for fewer than 25 cases.
Bonferroni-corrected P values for interaction for age, sex, and race and ethnicity were non-significant (15 tests). On the East Coast of the United States, 10 mW/m2 corresponds to about a 770-kilometer (~478 mile) north-south distance.
IRR incidence rate ratio, CI confidence interval.
aTotal ocular melanoma included anatomical sites of choroid, ciliary body, conjunctiva, eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland.
bMutually adjusted for age, sex, and race and ethnicity race and ethnicity (non-Hispanic White, others [Hispanic White, Black, Asian Pacific American, American Indian]) as appropriate, in addition to year of diagnosis and registry’s population size that was categorised into quartiles using census-based population size to create four roughly equal categories (Q1: Iowa, Utah, Seattle (Puget Sound) Registry, Atlanta (Metropolitan) Registry, Rural and Greater Georgia Registries, San Francisco-Oakland SMSA Registry, San Jose-Monterey Registry, Los Angeles Registry, and Hawaii; Q2: Louisiana, Illinois, and Greater CA Registry; Q3: New Mexico, New York, Connecticut, and New Jersey; Q4: Texas, Idaho, Massachusetts, and Kentucky).
cMelanoma in other sites combined included anatomical sites of eye NOS, overlapping region of eye and adnexa, orbit NOS, retina, cornea, and lacrimal gland.
dOthers included not a paired site; only one side or side unspecified; bilateral, single primary; paired site: midline tumour; paired site, but no information concerning laterality.