Table 2.
Potential factors associated with oxygen need <2 L/min after admission.
| Variables | n/N | Univariate model | Multivariate model | ||
|---|---|---|---|---|---|
| HR [95% CI] | p-Value | HR [95% CI] | p-Value | ||
| Characteristics at baseline | |||||
| Age ≥ 60 (years) | 65/132 | 0.45 [0.21–0.96] | 0.04 | 1.91 [0.49–7.4] | 0.35 |
| Sex (M) | 86/132 | 0.8 [0.37–1.8] | 0.59 | – | – |
| Obesity (yes) | 14/132 | 0.55 [0.15–1.99] | 0.36 | – | – |
| Diabetes, no. (%) | 25/132 | 0.94 [0.37–2.35] | 0.89 | – | – |
| Chronic respiratory disease, no. (%) | 22/132 | 0.31 [0.10–0.9] | 0.03 | 0.16 [0.02–1.08] | 0.06 |
| Chronic cardiac disease, no. (%) | 57/132 | 0.79 [0.38–1.7] | 0.55 | – | – |
| Immunocompromised, no. (%) | 11/132 | 0.56 [0.15–2.1] | 0.37 | – | – |
| Biological abnormalities at D2 | |||||
| PMN count <8,000/mm3 | 82/94 | 2.37 [0.43–12.9] | 0.31 | – | – |
| Lymphocyte count ≥1,000/mm3 | 49/94 | 3.47 [1.39–8.7] | 0.008 | 0.49 [0.11–2.2] | 0.35 |
| Eosinophil count ≥100/mm3 | 45/94 | 5.5 [2.19–13.8] | <0.001 | 3.71 [1.06–12.9] | 0.04 |
| CRP <80 mg/L | 56/87 | 22.1 [4.71–103] | <0.001 | 26.28 [4.07–169.8] | <0.001 |
| Treatment strategies | |||||
| No treatment** | 114/132 | 1* | – | 1* | - |
| Corticosteroids | 18/132 | 0.04 [0.05–0.3] | 0.003 | 0.12 [0.08–1.7] | 0.11 |
1* indicates the reference category. No treatment** was defined as patients who have had no treatment including lopinavir–ritonavir or antibiotics. Multivariate Cox model regression was used to identify the potential factors associated with oxygen need <2 L/min at day 2 of admission.
n/N, number/total; HR, hazard ratio; CI, confidence interval; PMN, polymorphonuclear; CRP, C-reactive protein.
"-" Not applicable.