Table 2.
Univariate Cox regression analysis based on histological features.
| Category | n (%) | Overall Survival | Progression Free Survival | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P - value | HR | 95% CI | P - value | ||
| Tumor location | |||||||
| Superior lobe of left lung | 222 (24.7) | 1.000 | 1.000 | ||||
| Inferior lobe of left lung | 148 (16.5) | 0.694 | 0.365∼1.325 | 0.269 | 0.796 | 0.487∼1.301 | 0.363 |
| Superior lobe of right lung | 293 (32.6) | 1.413 | 0.774∼2.580 | 0.261 | 1.054 | 0.632∼1.757 | 0.840 |
| Middle lobe of right lung | 79 (8.8) | 0.643 | 0.353∼1.170 | 0.148 | 0.613 | 0.379∼0.994 | 0.047 |
| Inferior lobe of right lung | 157 (17.5) | 1.274 | 0.606∼2.680 | 0.522 | 1.341 | 0.754∼2.383 | 0.318 |
| Pulmonary lobectomy | |||||||
| No | 302 (33.6) | 1.000 | 1.000 | ||||
| Yes | 597 (66.4) | 4.461 | 2.155∼9.236 | <0.001 | 5.555 | 3.075∼10.037 | <0.001 |
| Segmentectomy | |||||||
| No | 715 (79.5) | 1.000 | 1.000 | ||||
| Yes | 184 (20.5) | 0.167 | 0.053∼0.530 | 0.002 | 0.086 | 0.027∼0.269 | <0.001 |
| Wedge resection | |||||||
| No | 787 (87.5) | 1.000 | 1.000 | ||||
| Yes | 112 (12.5) | 0.244 | 0.077∼0.771 | 0.016 | 0.239 | 0.098∼0.582 | 0.002 |
| Total pneumonectomy | |||||||
| No | 893 (99.3) | 1.000 | 1.000 | ||||
| Yes | 6 (0.7) | 2.469 | 0.607∼10.037 | 0.207 | 4.555 | 1.685∼12.314 | 0.003 |
| Tumor diameter (cm) | |||||||
| <2.25 | 645 (71.7) | 1.000 | 1.000 | ||||
| ≥2.25 | 254 (28.3) | 4.524 | 2.989∼6.849 | <0.001 | 5.546 | 3.957∼7.773 | <0.001 |
| Number of lymph node dissection | |||||||
| <10 | 433 (48.2) | 1.000 | 1.000 | ||||
| 10∼19 | 380 (42.3) | 3.220 | 1.847∼5.611 | <0.001 | 3.237 | 2.022∼5.181 | <0.001 |
| ≥20 | 86 (9.6) | 1.421 | 0.897∼2.249 | 0.134 | 1.782 | 1.234∼2.575 | 0.002 |
| Histological type | |||||||
| Adenocarcinoma | 793 (88.2) | 1.000 | 1.000 | ||||
| Non-adenocarcinoma | 106 (11.8) | 2.362 | 1.478∼3.773 | <0.001 | 2.499 | 1.710∼3.651 | <0.001 |
| Differentiated degree | |||||||
| Poorly differentiated | 101 (11.2) | 1.000 | 1.000 | ||||
| Moderately differentiated | 676 (75.2) | 0.242 | 0.109∼0.536 | <0.001 | 0.141 | 0.066∼0.303 | <0.001 |
| High differentiation | 122 (13.6) | 0.401 | 0.252∼0.637 | <0.001 | 0.370 | 0.255∼0.537 | <0.001 |
| Pathological stage | |||||||
| Stage I | 707 (78.6) | 1.000 | 1.000 | ||||
| Stage II | 87 (9.7) | 106.771 | 46.118∼247.190 | <0.001 | 104.645 | 59.948∼182.667 | <0.001 |
| Stage III | 105 (11.7) | 31.486 | 13.033∼76.066 | <0.001 | 26.923 | 14.999∼48.326 | <0.001 |
| T-staging | |||||||
| T1 | 544 (60.5) | 1.000 | 1.000 | ||||
| T2 | 314 (34.9) | 19.450 | 8.270∼45.745 | <0.001 | 41.306 | 20.460∼83.388 | <0.001 |
| T3 | 29 (3.2) | 8.058 | 3.808∼17.052 | <0.001 | 11.142 | 6.006∼20.670 | <0.001 |
| T4 | 12 (1.3) | 3.693 | 2.250∼6.063 | <0.001 | 5.155 | 3.426∼7.757 | <0.001 |
| N-staging | |||||||
| N0 | 743 (82.6) | 1.000 | 1.000 | ||||
| N1 | 59 (6.6) | 75.332 | 25.123∼225.879 | <0.001 | 92.986 | 35.517∼243.449 | <0.001 |
| N2 | 92 (10.2) | 40.410 | 23.350∼69.936 | <0.001 | 60.493 | 38.577∼94.859 | <0.001 |
| N3 | 5 (0.6) | 13.078 | 6.907∼24.762 | <0.001 | 20.647 | 12.599∼33.834 | <0.001 |