Table 5.
Univariate Cox regression analysis based on complex indexes of inflammation and nutrition.
| Category | Overall Survival | Progression Free Survival | ||||||
|---|---|---|---|---|---|---|---|---|
| n (%) | HR | 95% CI | P - value | n (%) | HR | 95% CI | P - value | |
| Inflammatory complex index | ||||||||
| NLR | ||||||||
| Below | 424 (47.2) | 1.000 | 327 (36.4) | 1.000 | ||||
| Above | 475 (52.8) | 2.529 | 1.604∼3.987 | <0.001 | 572 (63.6) | 2.176 | 1.471∼3.218 | <0.001 |
| PLR | ||||||||
| Below | 641 (71.3) | 1.000 | 649 (72.2) | 1.000 | ||||
| Above | 258 (28.7) | 2.062 | 1.378∼3.084 | <0.001 | 250 (27.8) | 1.675 | 1.202∼2.334 | 0.002 |
| SII | ||||||||
| Below | 611 (68.0) | 1.000 | 592 (65.9) | 1.000 | ||||
| Above | 288 (32.0) | 2.511 | 1.685∼3.742 | <0.001 | 307 (34.1) | 1.949 | 1.413∼2.688 | <0.001 |
| LMR | ||||||||
| Below | 408 (45.4) | 1.000 | 547 (60.8) | 1.000 | ||||
| Above | 491 (54.6) | 0.572 | 0.383∼0.856 | 0.007 | 352 (39.2) | 0.562 | 0.392∼0.804 | 0.002 |
| PIV | ||||||||
| Below | 426 (47.4) | 1.000 | 240 (26.7) | 1.000 | ||||
| Above | 473 (52.6) | 2.151 | 1.398∼3.311 | <0.001 | 659 (73.3) | 2.372 | 1.495∼3.764 | <0.001 |
| Nutrient complex index | ||||||||
| FAR | ||||||||
| Below | 527 (58.6) | 1.000 | 614 (68.3) | 1.000 | ||||
| Above | 372 (41.4) | 2.545 | 1.683∼3.848 | <0.001 | 285 (31.7) | 2.538 | 1.839∼3.504 | <0.001 |
| FPR | ||||||||
| Below | 627 (69.7) | 1.000 | 594 (66.1) | 1.000 | ||||
| Above | 272 (30.3) | 2.073 | 1.391∼3.090 | <0.001 | 305 (33.9) | 2.133 | 1.546∼2.943 | <0.001 |
| RAR | ||||||||
| Below | 606 (67.4) | 1.000 | 606 (67.4) | 1.000 | ||||
| Above | 293 (32.6) | 1.713 | 1.147∼2.559 | <0.001 | 293 (32.6) | 1.699 | 1.229∼2.350 | 0.001 |
| AGR | ||||||||
| Below | 528 (58.7) | 1.000 | 100 (11.1) | 1.000 | ||||
| Above | 371 (41.3) | 0.527 | 0.337∼0.825 | 0.005 | 799 (88.9) | 0.379 | 0.258∼0.556 | <0.001 |
| ALI | ||||||||
| Below | 592 (65.9) | 1.000 | 596 (66.3) | 1.000 | ||||
| Above | 307 (34.1) | 0.271 | 0.148∼0.496 | <0.001 | 303 (33.7) | 0.393 | 0.257∼0.600 | <0.001 |
| PNI | ||||||||
| Below | 198 (22.0) | 1.000 | 199 (22.1) | 1.000 | ||||
| Above | 701 (78.0) | 0.460 | 0.302∼0.700 | <0.001 | 700 (77.9) | 0.541 | 0.384∼0.764 | <0.001 |
| AAPR | ||||||||
| Below | 368 (40.9) | 1.000 | 341 (37.9) | 1.000 | ||||
| Above | 531 (59.1) | 0.425 | 0.280∼0.644 | <0.001 | 558 (62.1) | 0.505 | 0.366∼0.698 | <0.001 |
| CAR | ||||||||
| Below | 386 (42.9) | 1.000 | 385 (42.8) | 1.000 | ||||
| Above | 513 (57.1) | 2.287 | 1.432∼3.652 | 0.001 | 514 (57.2) | 2.112 | 1.465∼3.044 | <0.001 |
| APR | ||||||||
| Below | 547 (60.8) | 1.000 | 555 (61.7) | 1.000 | ||||
| Above | 352 (39.2) | 1.878 | 1.256∼2.809 | 0.002 | 344 (38.3) | 1.947 | 1.410∼2.688 | <0.001 |
| FFA/Alb | ||||||||
| Below | 431 (47.9) | 1.000 | 300 (33.4) | 1.000 | ||||
| Above | 468 (52.1) | 0.541 | 0.351∼0.833 | 0.005 | 599 (66.6) | 0.676 | 0.488∼0.936 | 0.018 |
FAR, The fibrinogen/albumin ratio; SII, Systemic immune-inflammatory index; FPR, fibrinogen to prealbumin ratio; NLR, Neutrophil/lymphocyte ratio; APR, Alkaline phosphatase to prealbumin ratio; PIV, Pan-immune inflammatory value; CAR, C-reactive protein/albumin ratio; PLR, platelet/lymphocyte ratio; RAR, Red blood cell distribution width/albumin ratio; LMR, lymphocyte/monocyte ratio; PNI, Prognostic nutritional index; FFA/Alb, serum free fatty acid/albumin ratio; AGR, serum albumin globulin ratio; ALI, advanced lung cancer inflammation index; AAPR, albumin to alkaline phosphatase ratio.