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. 2024 May 24;14:1378135. doi: 10.3389/fonc.2024.1378135

Table 6.

Multivariate Cox analysis of overall survival and progression-free survival.

Factor Overall Survival Progression Free Survival
HR 95%CI P - value HR 95%CI P - value
Perineural invasion
 Without vs. With 2.568 1.013∼6.512 0.047
Pathological stage
 Stage I 1.000 1.000
 Stage II 46.731 6.832∼319.651 <0.001 29.655 6.914∼127.191 <0.001
 Stage III 16.964 4.276∼67.295 <0.001 7.971 2.913∼21.813 <0.001
FFA/Alb
 <9.812 vs. ≥9.812 0.576 0.344∼0.962 0.035 0.655 0.430∼0.998 0.049
Smoking status
 Never vs. Current/past 2.052 1.121∼3.754 0.020
Adjuvant radiation therapy
 No vs. Yes 3.501 2.136∼5.739 <0.001
LNs
 <10 1.000
 10∼19 0.481 0.255∼0.909 0.024
 ≥20 0.646 0.402∼1.037 0.070
T stage
 T1 1.000
 T2 2.551 0.968∼6.719 0.058
 T3 2.508 1.093∼5.752 0.030
 T4 1.939 1.139∼3.303 0.015
N stage
 N0 1.000
 N1 3.760 0.656∼21.561 0.137
 N2 3.013 0.879∼10.332 0.079
 N3 2.558 1.128∼5.803 0.025
Tumor location
 Superior lobe of left lung 1.000
 Inferior lobe of left lung 0.530 0.288∼0.975 0.041
 Superior lobe of right lung 0.847 0.450∼1.596 0.607
 Middle lobe of right lung 0.613 0.335∼1.120 0.112
 Inferior lobe of right lung 0.757 0.375∼1.527 0.437

FFA/Alb, serum free fatty acid/albumin ratio; LNs, Number of lymph nodes removed surgically.