Table 1.

Hyperglycemia-ischemia (HGI) specific change in phosphorylation of signaling proteins involved in the NF-κB pathway.

Phospho-protein site	Change in phosphorylation	Reference to NF-κB involvement
P38 MAPK (Phospho-Thr180)	Up	(21–23)
AKT1 (Phospho-Tyr474)	Up	(24)
Ras-GRF1 (Phospho-Ser916)	Up	(25, 26)
HDAC1 (Phospho-Ser421)	Up	(27)
NF-κB-p100 (Phopho-Ser872)	Up	(28)
BLNK (Phopho-Tyr96)	Up	(29)
BLNK (Phopho-Tyr84)	Up
IKK gamma (Phopho-Ser85)	UP	(30)
PKC theta (Phopho-Ser676)	Down	(31, 32)
PKR (Phospho-Thr446)	Down	(33)
PKR (Phopho-Thr451)	Down
PKC beta (Phospho-Ser661)	Down
PKC zeta (Phospho-Thr410)	Down	(31, 32, 34)
HDAC5 (Phopho-Ser259)	Down
SAPK/JNK (Phospho-Thr183)	Down
IκB-alpha (Phopho-Ser32/36)	Down	(35)
NF-κB-p65 (Phopho-Thr435)	Down	(36)
LCK (Phopho-Tyr505)	Down