Table 2.
Horizontal pleiotropy analysis for IVs of 30 GM taxa associated with epilepsy.
| Exposure | Outcome | MR-Egger intercept test | MR-PRESSO global test | ||
|---|---|---|---|---|---|
| Egger_ intercept | p-value | RSS obs | p-value | ||
| Genus Phascolarctobacterium id.2168 | GE | 5.68 | 0.68 | 7.76 | 0.50 |
| Genus Oxalobacter id.2978 | GE | 8.16 | 0.52 | 10.06 | 0.57 |
| Genus Ruminococcaceae UCG013 id.11370 | GE | 10.55 | 0.31 | 11.04 | 0.54 |
| Genus Marvinbryantia id.2005 | GE | 5.76 | 0.33 | 12.50 | 0.43 |
| Order Mollicutes RF9 id.11579 | GE | 12.72 | 0.24 | 15.28 | 0.34 |
| Class Gammaproteobacteria id.3303 | GE | 5.61 | 0.23 | 10.28 | 0.26 |
| Genus Eubacterium nodatum group id.11297 | FE | 0.03 | 0.41 | 6.44 | 0.88 |
| Genus Bifidobacterium id.436 | FE | −0.01 | 0.47 | 19.22 | 0.17 |
| Genus Bilophila id.3170 | FE | 0.02 | 0.60 | 15.34 | 0.40 |
| Genus Erysipelatoclostridium id.11381 | FE | −0.01 | 0.77 | 10.49 | 0.83 |
| Genus Flavonifractor id.2059 | FE | 0.02 | 0.04 | 3.71 | 0.69 |
| Family Veillonellaceae id.2172 | CAE | 0.00 | 0.69 | 5.29 | 0.94 |
| Phylum Bacteroidetes id.905 | CAE | 0.00 | 0.67 | 6.41 | 0.70 |
| Phylum Verrucomicrobia id.3982 | CAE | 0.00 | 0.48 | 4.09 | 0.83 |
| Class Bacteroidia id.912 | CAE | 0.00 | 0.30 | 5.84 | 0.75 |
| Order Bacteroidales id.913 | CAE | 0.00 | 0.30 | 5.84 | 0.76 |
| Genus Anaerostipes id.1991 | CAE | −0.01 | 0.37 | 4.94 | 0.48 |
| Genus Desulfovibrio id.3173 | CAE | 0.04 | 0.40 | NA | NA |
| Genus Ruminococcaceae NK4A214 group id.11358 | CAE | 0.00 | 0.96 | 1.11 | 0.90 |
| Genus Oscillibacter id.2063 | CAE | 0.00 | 0.93 | 12.74 | 0.19 |
| Family Prevotellaceae id.960 | JAE | −0.01 | 0.09 | 7.96 | 0.71 |
| Family Rhodospirillaceae id.2717 | JAE | 0.00 | 0.55 | 12.10 | 0.55 |
| Order Rhodospirillales id.2667 | JAE | 0.00 | 0.72 | 12.79 | 0.48 |
| Genus Eggerthella id.819 | JAE | 0.00 | 0.44 | 1.81 | 0.83 |
| Genus Parabacteroides id.954 | JAE | 0.00 | 0.79 | 1.92 | 0.81 |
| Genus Ruminococcaceae UCG004 id.11362 | JAE | 0.00 | 0.67 | 5.43 | 0.63 |
| Genus Ruminococcaceae UCG010 id.11367 | JAE | −0.01 | 0.42 | NA | NA |
| Genus Eubacterium nodatum group id.11297 | JAE | 0.00 | 0.29 | 5.86 | 0.74 |
| Genus Candidatus Soleaferrea id.11350 | JAE | 0.01 | 0.47 | 5.89 | 0.57 |
| Genus Lachnospiraceae UCG010 id.11330 | JAE | 0.00 | 0.62 | 3.51 | 0.73 |
GE, generalized epilepsy; FE, focal epilepsy; CAE, child absence epilepsy; JAE, juvenile absence epilepsy; MR-PRESSO, MR pleiotropy residual sum and outlier.