TABLE 1.

Correlations between AlphaFold2-Multimer and HADDOCK docking predictions across various binding metrics. Significant correlations are shown in bold.

p-values/R 2		HADDOCK			AlphaFold2 multimer
		van der Waals energy	PRODIGY ΔG	FoldX ΔG	van der Waals energy	PRODIGY ΔG	FoldX ΔG
HADDOCK	van der Waals Energy		0.9867	0.0830	0.0037	0.0122	0.0384
	PRODIGY ΔG	<0.0001		0.6095	0.8560	0.8935	0.0366
	FoldX ΔG	0.0210	<0.0001		0.0515	0.0419	0.0582
AlphaFold2 Multimer	van der Waals Energy	0.6349	<0.0001	0.0713		0.5741	0.1605
	PRODIGY ΔG	0.3852	<0.0001	0.1045	<0.0001		0.0161
	FoldX ΔG	0.1206	0.1267	0.0548	0.0010	0.3178

Bold indicates significant p-values (alpha < 0.05) and their corresponding correlations.