Table 3. Fully Adjusted Sex-Stratified Cox Proportional Hazards Regression Models for All-Cause, CVD, and Cancer Mortality According to Tobacco Smoking Status.

Variable	Hazard ratio (95% CI)
	All-cause mortality	CVD mortality	Cancer mortality
Females
Current tobacco use
Cannabis use
Heavy	2.25 (1.12-4.53)	2.56 (1.43-15.36)	3.52 (1.50-8.33)
Moderate	1.57 (0.68-3.63)	2.31 (0.39-13.56)	2.02 (1.04-3.92)
Low	1.59 (0.96-2.66)	0.62 (0.07-5.72)	2.10 (0.69-4.39)
Never	1 [Reference]	1 [Reference]	1 [Reference]
Past tobacco use
Cannabis use
Heavy	0.87 (0.38-1.99)	NA	1.03 (0.41-2.59)
Moderate	0.87 (0.49-1.57)	2.96 (0.92-9.53)	0.66 (0.30-1.45)
Low	1.09 (0.79-1.53)	1.32 (0.51-3.43)	1.27 (0.87-1.87)
Never	1 [Reference]	1 [Reference]	1 [Reference]
Never tobacco use
Cannabis use
Heavy	1.68 (0.23-11.97)	2.98 (1.67-6.61)	NA
Moderate	1.43 (0.64-3.22)	2.39 (0.32-7.59)	1.33 (0.49-3.59)
Low	0.81 (0.56-1.21)	0.87 (0.27-2.82)	0.86 (0.54-1.34)
Never	1 [Reference]	1 [Reference]	1 [Reference]
Males
Current tobacco use
Cannabis use
Heavy	1.51 (0.83-2.73)	1.11 (0.32-3.89)	2.44 (1.14-5.23)
Moderate	1.15 (0.64-2.05)	0.90 (0.22-2.92)	1.14 (0.46-2.82)
Low	1.09 (0.71-1.68)	0.53 (0.18-1.58)	1.65 (0.94-2.91)
Never	1 [Reference]	1 [Reference]	1 [Reference]
Past tobacco use
Cannabis use
Heavy	1.25 (0.75-2.08)	1.10 (0.33-3.63)	1.15 (0.57-2.32)
Moderate	0.78 (0.46-1.30)	0.68 (0.21-2.20)	0.83 (0.43-1.62)
Low	0.95 (0.72-1.25)	0.83 (0.46-1.52)	0.99 (0.68-1.44)
Never	1 [Reference]	1 [Reference]	1 [Reference]
Never tobacco use
Cannabis use
Heavy	0.85 (0.21-3.43)	NA	NA
Moderate	0.85 (0.40-1.80)	0.56 (0.07-4.07)	0.78 (0.29-2.12)
Low	0.83 (0.43-1.91)	0.71 (0.35-1.48)	0.61 (0.28-1.99)
Never	1 [Reference]	1 [Reference]	1 [Reference]

Abbreviations: CVD, cardiovascular disease; NA, not applicable.