TABLE 4.
Epigenetic age acceleration comparing PLWH with detected (VL > 50) and PLWH with undetected (VL ≤ 50) copies/mL to matched SN participants, and the two PLWH groups to each other, at each visit.
| Visit 1 (pre-HAART) | Visit 2 (post-HAART) | |||
|---|---|---|---|---|
| Difference in the PLWH group mean from the matched SN group, years or relative units (p1)a | Mean in the PLWH group, years or relative units (p2)b | Difference in the PLWH group mean from the matched SN group, years or relative units (p1)a | Mean in the PLWH group, years or relative units (p2)b | |
| Undetected PLWHc | ||||
| AAR | 6.2 (<0.001) | 3.4 | 5.4 (<0.001) | 2.1 |
| EEAA | 10.9 (<0.001) | 6.2 | 6.4 (<0.001) | 1.7 |
| PEAA | 9.0 (<0.001) | 5.1 | 5.2 (<0.001) | 1.1 |
| GEAA | 0.0 (0.933) | −0.1 | 0.5 (0.408) | 0.2 |
| aaDNAmTL | −0.502 (<0.001) | −0.272 | −0.342 (<0.001) | −0.103 |
| Detected PLWHd | ||||
| AAR | 6.9 (<0.001) | 4.2 (0.375) | 6.9 (<0.001) | 3.3 (0.205) |
| EEAA | 14.0 (<0.001) | 8.4 (0.075) | 10.6 (<0.001) | 5.2 (0.009) |
| PEAA | 12.2 (<0.001) | 7.2 (0.053) | 9.8 (<0.001) | 5.2 (0.001) |
| GEAA | 1.5 (0.018) | 0.8 (0.138) | 1.5 (0.56) | 1.1 (0.249) |
| aaDNAmTL | −0.598 (<0.001) | −0.387 (0.012) | −0.473 (<0.001) | −0.232 (0.007) |
a: Difference between mean epigenetic values at indicated visit of the PLWH group and matched SN controls (PLWH group mean–SN group mean) in years (AAR, EEAA, PEAA, and GEAA) or relative units (aaDNAmTL); p1 is the p-value from the t-test comparing the PLWH group mean to the matched SN group mean (p-values bold if <0.05).
b: Mean epigenetic values at visit of the PLWH group in years (AAR, EEAA, PEAA, and GEAA) or relative units (aaDNAmTL); p2 is the p-value from the t-test comparing the detected PLWH mean to the undetected PLWH mean (p-values bold if <0.05).
c: PLWH stratified based on the undetected HIV VL at the post-HAART visit (< or = 50 copies/mL; n = 125).
d: PLWH stratified based on the detected HIV VL at the post-HAART visit (>50 copies/mL; n = 74).