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. 2024 May 24;4:1357889. doi: 10.3389/fbinf.2024.1357889

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Copyright © 2024 Zhang, Sehl, Shih, Breen, Li, Lu, Bream, Duggal, Martinson, Wolinsky, Martinez-Maza, Ramirez, Horvath and Jamieson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manhattan Plot of EWAS over the course of HAART Initiation in Detected PLWH Group. Plotted are the HAART-related CpGs in the Detected (plasma HIV VL > 50 copies/mL at the post-HAART visit, n = 67) PLWH group. Top CpGs are labeled with proximal genes, the x-axis represents the location of the CpG on the chromosome, and the y-axis represents the signed -log10 p-value. The positive y-values (signed -log10 p-value) are CpGs that gain methylation with HAART initiation (blue), while the negative y-values are CpGs that lose methylation with HAART initiation (gold).