Table 2. Audiologic Features Stratified by Presence or Absence of Self-Reported Hearing Loss for 100 Survivors of Cisplatin-Treated Germ Cell Tumorsa.
| Audiologic feature | Participants, No. (%) | Unadjusted P value | ||
|---|---|---|---|---|
| Total population (N = 100) | Hearing loss (n = 54)b | No hearing loss (n = 46) | ||
| Audiometrically measured hearing, median (range), dB HL | ||||
| High-frequency PTA at TPS-2 (assessment 2)c | 38.0 (4 to 94) | 47.5 (4 to 94) | 24.0 (4 to 67) | <.001 |
| Progression of hearing loss: change since TPS-1 (assessment 1) | 7.5 (−21 to 30) | 8.3 (−21 to 30) | 6.8 (−6 to 19) | .09 |
| ASHA: Clinical Severity of Hearing Lossd | ||||
| Normal | 22 (22) | 8 (15) | 14 (30) | .002 |
| Slight | 13 (13) | 3 (6) | 10 (22) | |
| Mild | 19 (19) | 11 (20) | 8 (17) | |
| Moderate | 25 (25) | 13 (24) | 12 (26) | |
| Moderately severe | 14 (14) | 12 (22) | 2 (4) | |
| Severe | 5 (5) | 5 (9) | 0 | |
| Profound | 2 (2) | 2 (4) | 0 | |
| Speech perception, median (range) | ||||
| Speech recognition threshold, dB HLe | 10.0 (0 to 38) | 12.5 (0 to 38) | 10.0 (0 to 25) | .02 |
| Change since TPS-1 (assessment 1) | 0.0 (−13 to 25) | 1.3 (−13 to 25) | 0.0 (−10 to 15) | .72 |
| Word recognition in quiet (%)e | 98 (55 to 100) | 96 (55 to 100) | 98 (92 to 100) | .01 |
| Change since TPS-1 (assessment 1) | 0.0 (−41 to 18) | 0.0 (−41 to −18) | 0.0 (−8 to −4) | .91 |
| Speech-in-noise performance, WIN, dB SNRe | ||||
| Total correctly recognized words | 25.5 (12 to 30) | 24.5 (12 to 28) | 26.0 (21 to 30) | <.001 |
| SNR-50, dB SNR | 5.6 (2 to 17) | 6.4 (4 to 17) | 5.2 (2 to 10) | <.001 |
| Clinical scaling: WIN performance (dB SNR)e | ||||
| Normal ability (2.0 to 6.0) | 65 (65) | 25 (46) | 40 (87) | <.001 |
| Mild difficulty (6.8 to 10) | 27 (27) | 21 (39) | 6 (13) | |
| Moderate difficulty (10.8 to 14.8) | 5 (5) | 5 (9) | 0 | |
| Severe difficulty (15.6 to 19.6) | 3 (3) | 3 (6) | 0 | |
| Problems hearing in crowds | 39 (39) | 39 (74) | 0 | <.001 |
| Communication partners report patient HL | 30 (36) | 26 (57) | 4 (11) | <.001 |
| Use of hearing aids | 3 (4) | 3 (7) | 0 | .35 |
| Hearing Handicap Inventory–Adultsf | ||||
| Total Score, median (range) (maximum 100) | 10.0 (0 to 92) | 10.0 (0 to 92) | NA | NA |
| Degree of handicap | ||||
| No handicap (0-16) | 28 (62) | 28 (62) | NA | NA |
| Mild-moderate handicap (17-42) | 7 (16) | 7 (16) | NA | NA |
| Severe handicap (>42) | 10 (22) | 10 (22) | NA | NA |
Abbreviations: dB HL, decibel reference to hearing level; dB SNR, decibel signal-to-noise ratio; HHIA, Hearing Handicap Inventory Adult; NA, not applicable; PTA, Pure-Tone Average; TPFQ, Tinnitus Primary Frequency Questionnaire; TPS-1, The Platinum Study-1; TPS-2, The Platinum Study-2; WIN, words in noise test.
Data are from TPS-2 measurements unless otherwise specified. Differences between features from initial assessment (TPS-1) and updated assessment (TPS-2) are displayed as ‘change’ in that feature.
Patients were classified with self-reported hearing loss as defined in the eAppendix in Supplement 1.
PTA across both ears: 4000, 6000, 8000, 10 000, and 12 000.
Defined by High-frequency pure-tone average and clinical criteria set forth by the American Speech-Language-Hearing Association (ASHA) (see the eMethods and eAppendix in Supplement 1).
Measurements and definitions for speech recognition threshold, speech recognition threshold change since TPS-1, word recognition in quiet, word recognition in quiet change since TPS-1, speech-in-noise performance, words-in-noise test, and WIN test normative rating and clinical scaling are explained in the eMethods and eAppendix in Supplement 1.
Per clinical standards, the HHIA was only administered to patients with self-reported hearing loss (ie, 54 patients). Of these 54 patients, 45 answered the HHIA.
The total population is shown in the second column, followed by those with self-reported hearing loss (third column) and those without self-reported hearing loss (fourth column). Significant differences using an unadjusted univariable analysis between those with or without hearing loss are in the far right column.