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. 2024 Jun 6;10(7):912–922. doi: 10.1001/jamaoncol.2024.1233

Table 3. Multivariable Regression Models of Factors Associated With Speech-in-Noise Performance Measured With the Words-in-Noise (WIN) Test, and With Progression of Audiometrically Defined Hearing Loss.

Factor β (95% CI) P value
Speech-in-noise performance (WIN)
Hypercholesterolemia 0.88 (0.08 to 1.69) .03
Education
Not college graduate 1 [Reference] NA
College graduate −1.43 (−2.29 to −0.56) .002
Postgraduate −1.22 (−2.18 to −0.26) .01
Audiometrically measured hearinga 0.07 (0.06 to 0.09) <.001
Temporal progression of audiometrically measured hearinga
Hypercholesterolemia −4.38 (−7.42 to −1.34) .01
Age at TPS-1 (Assessment 1) 0.33 (0.15 to 0.50) <.001
Time since baseline (TPS-1, Assessment 1) 0.12 (0.02 to 0.23) .02
Hypertension 1.96 (−1.15 to 5.07) .22

Abbreviations: HL, hearing loss; NA, not applicable; TPS-1, The Platinum Study, initial baseline assessment; TPS-2, The Platinum Study, follow-up assessment.

a

Hearing variable defined as the average of both ears across the higher frequencies measured (ie, pure-tone average of 4, 6, 8, 10, and 12 kHz).