Table 2.

Examples of ferroptosis inducers

Inducers	Target	Function	References
Sulfasalazine	SLC7A11	Inhibit cystine uptake	[183]
Cisplatin	GSH	Induce lipid peroxidation	[352]
Dihydroartemisinin, artesunnate	Ferritin	Increase iron overload	[353]
Statins	HMGCR, GPX4	Block GPX4 production	[40]
Gefitinib	ROS	Induce lipid peroxidation	[354]
Zalcitabine	Mitochondrial DNA stress	Induce STING1-mediated autophagy	[355]
Sorafenib	SLC7A11	Inhibit cystine uptake	[320]
Lapatinib, siramesine	Fe	Increase iron overload	[356]
Haloperidol	Dopamine receptor D2	Induce ER stress-dependent autophagy	[357]
Paclitaxel	TP53, SLC7A11	Inhibit cystine uptake and induce iron overload	[358]
Altretamine	GPX4	Inhibit GPX4 activity	[359]
Brefeldin A	Golgi	Induce Golgi stress	[360]
Buthionine sulfoximine (BSO)	GCL	Inhibit GSH produciton	[183]
Doxorubicin	HMOX1	Increase iron overload	[226]
Salinomycin	Ferritin	Induce ferritinophagy	[258]
Erastin	System xc−	Inhibit cystine uptake	[9]
FIN56	GPX4	Induce GPX4 degradation and inhibit the mevalonate pathway	[40]
FINO2	Fe	Increase iron overload and induce GPX4 degradation	[361]
iFSP1	AIFM2	Inhibit AIFM2	[107]
ML162, ML210, RSL3, diacylfuroxans, BCP-T.A	GPX4	Inhibit GPX4 activity	[97, 362, 363]
dGPX4, DC2, 8e	GPX4	Induce PROTAC-dependent GPX4 degradation	[364–366]
N6F11	GPX4	Induce TRIM25-dependent GPX4 degradation	[287]
Imidazole ketone erastin (IKE)	SLC7A11	Inhibit cystine uptake	[367]
FSEN1	AIFM2	Inhibit AIFM2	[368]
Metformin	SLC7A11	Inhibit UFMylation of SLC7A11	[369]
Rapamycin	GPX4	Induce autophagy-dependent GPX4 degradation	[98]
Dimethyl fumarate	ALOX5, STAT3	Induce ALOX5-dependent lipid peroxidation	[370]
Itaconic acid	Ferritin	Induce ferritinophagy	[260]
BAY 87-2243	Mitochondrial complex I	Induce mitochondrial-dependent ROS elevation	[371]
MMRi62	Ferritin	Induce ferritinophagy	[372]
NC-R17	GPX4	Induce proteasomal degradation of GPX4 via PROTAC	[373]