Table 3.
Examples of ferroptosis inhibitors
Class | Name | References |
---|---|---|
ACSL4 inhibitor | Triacsin C, troglitazone, rosiglitazone | [374–376] |
ALOX inhibitor | Zileuton, MK886, PD146176, baicalein, LOXBlock-1 | [33, 42, 45, 377, 378] |
DPP4 inhibitor | Vildagliptin, alogliptin, linagliptin | [30, 360] |
Iron chelator | Deferoxamine (DFO), 2,2-bipyridyl, ciclopirox olamine (CPX), deferiprone, pioglitazone | [9, 324, 379, 380] |
Lipid peroxidation inhibitor | Ferrostatins (e.g., ferrostatin-1, SRS11-92, SRS12-45, SRS13-35, SRS13-37, and SRS16-86), liproxstatin-1 | [9, 45] |
Lysosome and autophagy inhibitor | Ammonium chloride, bafilomycin A1, chloroquine, wortmannin, 3-methyladenine, cryptotanshinone, CA-074Me, pepstatin A, E64 | [381–385] |
Mitochondrial ROS inhibitor | XJB-5–131, JP4-039, mitoTEMPO, MitoQ | [226, 386, 387] |
NOX inhibitor | 2-acetylphenothiazine, diphenyleneiodonium chloride (DPI) | [9, 30] |
Broad-spectrum antioxidant | Vitamin E, vitamin K, n-acetylcysteine (NAC), butylated hydroxyltoluene (BHT), GSH and CoQ10 | [9, 108, 388–390] |
FDFT1 inhibitor | Zaragozic acid A, YM-53,601 | [40] |
STING1 inhibitor | H-151 | [355] |
CTSB inhibitor | CA-074Me | [181] |