Table 1.

Study Population, Intervention, Comparison and Outcomes (PICO)

Patient	1) Women undergoing pre-pectoral implant-based breast reconstruction with or without ADM 2) Women undergoing reconstruction for cancer treatment or prophylaxis 3) Immediate or delayed reconstruction 4) Unilateral or bilateral reconstruction
Intervention	Use of acellular dermal matrices (ADM) during breast reconstruction procedures
Comparison	Non-use of ADM during breast reconstruction procedures
Outcome	Operative success, defined by the following: 1) Complications 2) Failure 3) Patient quality of life

Outcome 1 — complications — will include short-term outcomes such as seroma, haematoma, wound breakdown, nipple necrosis, infection and long-term outcomes such as capsular contracture, rotation and rippling. Outcome 2 — failure — will be defined as complications resulting in implant removal or explantation. Outcome 3 — quality of life (QoL) — will encompass all QoL measuring tools used in included studies; follow-up should be for a minimum of 3 years