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. 2009 Mar 12;100(7):1180–1185. doi: 10.1111/j.1349-7006.2009.01157.x

Figure 2.

Figure 2

Cysts (a) or dilated glands (A) and hyperplasia (B) were frequent in the groups treated with N‐methyl‐N‐nitrosourea (MNU), dysplasia (C) being significantly increased in diabetic (db/db) mice treated with MNU. At week 30, adenocarcinomas were observed in 45% of db/db mice treated with MNU (D,E). H&E (d), p53 (E). Parietal cells recognized as H+/K+‐exchanging ATPase (H/K‐ATPase)‐positive were decreased or lacking in a hyperplastic area (F). Foveolar hyperplasia was recognized by a proliferation of periodic acid‐Schiff‐positive cells (G) and mucous cell hyperplasia, by mostly trefoil factor 2 (TFF2)‐positive cells (H). A tumor in which the expression of pepsinogen was decreased or lacking (I). Bar = 100 µM in (A–C, E–I), 20 µM in (D).