Table 2.
Histological findings
| Week | Group | Histological findings (number of mice) | ||||
|---|---|---|---|---|---|---|
| Survival | Cyst, dila* | Hyperplasia | Dysplasia | Adenocarcinoma | ||
| Week 21 | A: db/db + MNU | 19 | 15 (79%) | 10 (53%) | 7 (37%) | 0 |
| B: +/db + MNU | 16 | 13 (68%) | 8 (50%) | 1 (6%) ‡ | 0 | |
| C: misty + MNU | 12 | 8 (42%) | 5 (42%) | 1 (8%) ‡ | 0 | |
| D: db/db | 5 | 1 (5%) | 0 | 0 | 0 | |
| Week 30 | A: db/db + MNU | 11 | 11 | 11 | 10 (91%) | 5 (45%) |
| B: +/db + MNU | 14 | 11 (79%) | 11 (79%) | 6 (43%) § | 0 | |
| C: misty + MNU | 9 | 5 (56%) | 6 (67%) | 5 (56%) § | 0 | |
| D: db/db | 4 | 0 | 0 | 0 | 0 | |
*
Cyst or dilated glands.
‡
At week 21, P < 0.01 compared with Group A.
§
At week 30, P < 0.01 compared with Group A.