Table 1.

The status of p53 and expression of downstream genes.

	p53 states	cell type	Mcl‐1	Bcl‐XL	Bax	Bak	p16INK4a	p21WAF1/Cip1	Rb	c‐myc	Ras	HER2/neu
SK‐BR‐3 (HTB‐30)	Deletion & mutation [aa175]	IDC† ER(‐)‡ PgR(‐)§	++	+	+	+++				+ high	+ low	+ high
YMB‐1‐E (CRL1500, ZR‐75‐1)	intact	IDC ER(+) PgR(+)	++	++	+	+		+ high		+ high	+ low	+ high
MCF7 (HTB22)	intact	IDC ER(+) PgR(+)	++	+	+	+	−	+	wt	+ high	+ low	deletion/+ low
HBC4	intact	ER(‐)	++	++	+++	+	−			+ high	+ low
HBC5	Mutation [C242F (ttc)]		+++	+++	+	++
HTB26	Mutation [R284L (aaa)]	IDC ER(‐) PgR(‐)	+++	+++	++	++	−	+ low	wt	+ high	+ low	+ low
HMEC	intact	normal breast epitherial cell	+	++	+	+		+	wt	ND	ND	+ low
MCF10A	intact	spontaneously immortarized HMEC	+	+++	+	+		+	wt	ND	ND	+ low

^† : invasive ductal carcinoma,

^‡ ‡: ertrogen receptor,

^§ §: progesterone receptor