Table 2.
Histopathological response in gerbils
| Group | No. | Antrum | Corpus | Anti‐Hp IgG titer (A.I) | Serum gastin levels (pg/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mucosal thinckness (mm) | Neutrophils | Mono‐nuclear cells | Hyperplasia | Intestinal metaplasia | BrdU labeling index (%) | Mucosal thinckness (mm) | Neutrophils | Mono‐nuclear cells | Hyperplasia | Intestinal metaplasia | BrdU labeling index (%) | ||||
| A | 20 | 0.82 ± 0.25* | 2.1 ± 0.6* | 3.0 ± 0.2* | 2.9 ± 0.3* | 2.3 ± 0.7* | 24.6 ± 5.9* | 1.04 ± 0.26* | 1.3 ± 0.3* | 2.4 ± 0.3* | 2.4 ± 0.2* | 1.1 ± 0.4* | 14.1 ± 3.3* | 288.1 ± 44.7* | 1235.1 ± 373.1* |
| a1 | 6 | 0.35 ± 0.09 † | 2.9 ± 0.2 ‡ | 3.0 ± 0.0 ‡ | 1.3 ± 0.3 † | 0.0 ± 0.0 | 20.2 ± 6.3 ‡ | 0.64 ± 0.07 † | 1.0 ± 0.1 † | 1.0 ± 0.3 ‡ | 1.1 ± 0.2 ‡ | 0.0 ± 0.0 | 4.5 ± 1.5 | 14.3 ± 3.5 ‡ | ND |
| B | 10 | 0.48 ± 0.20 | 1.7 ± 0.3 | 2.3 ± 0.2 | 1.8 ± 0.6 | 0.7 ± 0.4 | 13.4 ± 4.2 | 0.77 ± 0.29 | 1.2 ± 0.3 | 1.6 ± 0.6 | 1.6 ± 0.5 | 0.3 ± 0.3 | 9.6 ± 2.1 | 175.8 ± 23.1 | 323.6 ± 114.4 |
| b1 | 7 | 0.30 ± 0.11 | 2.4 ± 0.2 | 2.4 ± 0.4 | 1.4 ± 0.2 | 0.0 ± 0.0 | 10.4 ± 3.8 | 0.54 ± 0.06 | 1.0 ± 0.0 | 1.1 ± 0.2 | 1.1 ± 0.3 | 0.0 ± 0.0 | 4.4 ± 1.0 | 8.8 ± 1.4 | ND |
| C | 13 | 0.60 ± 0.17 | 1.4 ± 0.3 | 2.1 ± 0.3 | 1.8 ± 0.3 | 0.6 ± 0.2 | 8.3 ± 1.8 | 0.77 ± 0.21 | 1.1 ± 0.0 | 1.5 ± 0.4 | 1.4 ± 0.2 | 0.5 ± 0.4 | 9.3 ± 2.3 | 137.1 ± 19.6 | 395.0 ± 68.3 |
| c1 | 7 | 0.19 ± 0.02 | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.7 ± 0.3 | 0.0 ± 0.0 | 7.2 ± 1.8 | 0.45 ± 0.08 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.0 ± 0.0 | 3.5 ± 1.3 | 0.8 ± 0.3 | ND |
| D | 16 | 0.20 ± 0.04 | 0.0 ± 0.0 | 0.4 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.1 | 4.4 ± 1.9 | 0.42 ± 0.04 | 0.0 ± 0.0 | 0.3 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 3.0 ± 0.8 | 1.4 ± 0.3 | 206.2 ± 18.6 |
| E | 5 | 0.62 ± 0.13 § | 1.9 ± 0.2 ¶ | 3.0 ± 0.0 ¶ | 2.8 ± 0.3 ¶ | 2.7 ± 0.3 § | 20.4 ± 4.8 § | 1.02 ± 0.18 ¶ | 1.5 ± 0.4 ¶ | 2.4 ± 0.2 ¶ | 2.0 ± 0.4 ¶ | 1.1 ± 0.4 ¶ | 13.7 ± 1.6 § | 498.4 ± 74.0 § | 807.6 ± 117.0 § |
| F | 5 | 0.41 ± 0.09 | 1.6 ± 0.2 | 2.5 ± 0.4 | 2.3 ± 0.3 | 1.0 ± 0.0 | 10.2 ± 2.4 | 0.86 ± 0.05 | 1.2 ± 0.3 | 2.0 ± 0.0 | 1.7 ± 0.6 | 0.7 ± 0.3 | 5.9 ± 2.1 | 115.2 ± 36.5 | 396.3 ± 61.6 |
| G | 5 | 0.34 ± 0.08 | 1.3 ± 0.3 | 2.0 ± 0.0 | 1.9 ± 0.4 | 0.6 ± 0.2 | 4.5 ± 1.6 | 0.71 ± 0.22 | 1.0 ± 0.1 | 1.4 ± 0.2 | 1.0 ± 0.0 | 0.5 ± 0.1 | 3.9 ± 1.6 | 102.0 ± 37.5 | 375.2 ± 89.1 |
| H | 6 | 0.19 ± 0.03 | 0.0 ± 0.0 | 0.3 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 2.1 ± 0.4 | 0.44 ± 0.06 | 0.0 ± 0.0 | 0.3 ± 0.1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 2.7 ± 0.9 | 1.3 ± 0.4 | 244.7 ± 8.8 |
*
P < 0.05 to group B and C;
†
P < 0.05 to group b1;
‡
P < 0.05 to group b1 and c1;
§
P < 0.05 to group F and G;
¶
P < 0.05 to group G; ND, not determined; Hp, H.pylori; BrdU, bromodeoxyuridine