Table 1.
The IC50 drug concentrations for a panel of chemotherapeutic drugs in MTA‐resistant and parental cells
| Cell lines | PC‐6 | PC‐6/MTA‐1.6 | PC‐6/MTA‐1.6‐2 | PC‐6/MTA‐4.0 | |||
|---|---|---|---|---|---|---|---|
| Drug | IC50(95% CI) | IC50(95% CI) | RR | IC50(95% CI) | RR | IC50(95% CI) | RR |
| Pemetrexed (μM) | 0.2253 (0.1689–0.3004) | 7.327 (4.156–12.92) | 32.52 | 7.513 (3.599–15.69) | 33.4 | 98.24 (31.11–310.2) | 436 |
| Methotrexate (nM) | 2.207 (1.244–3.303) | 5868 (1331–25880) | 2895 | 6542 (3591–11920) | 3227 | 21700 (8241–57150) | 9832 |
| Etoposide (nM) | 833.6 (542.1–1282) | 756.8 (537.8–1065) | 0.908 | 853.8 (581.4–1254) | 1.02 | 652.0 (502.9–845.3) | 0.782 |
| Docetaxel (nM) | 1.146 (0.4742–2.767) | 1.516 (0.5373–4.279) | 1.323 | 1.216 (0.3262–4.535) | 1.06 | 1.352 (0.7734–2.364) | 1.18 |
| Vinorelbine (pM) | 29.11 (18.96–44.69) | 19.08 (11.72–31.07) | 0.655 | 23.44 (14.13–38.87) | 0.81 | 36.00 (25.20–51.43) | 1.237 |
| Cisplatin (μM) | 30.19 (2.034–395.6) | 26.85 (9.783–73.68) | 0.889 | 46.82 (8.081–271.3) | 1.55 | 46.35 (14.33–150.0) | 1.535 |
MTA, pemetrexed; RR, resistance ratio: (IC50 in resistant subline)/(IC50 in the parental cells).