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Level of intracellular nucleosides and nucleotides in (a,c) MIAPaCa‐2 and (b,d) MIAPaCa‐2/dFdCyd cells. After incubation with (a,b) dFdCyd and (c,d) TAS‐106, intracellular concentrations of the drug (•), its monophosphate (○), diphosphate (□) and triphosphate (▵) form was measured by high‐performance liquid chromatography as described in Materials and Methods. Values are mean ± standard deviation for three experiments.
