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Table 3.

Metabolic enzyme activities of MIAPaCa‐2 and its dFdCyd‐resistant cells, MIAPaCa‐2/dFdCyd

Enzyme Enzyme activity (nmol/min/mg protein)
MIAPaCa‐2 MIAPaCa‐2/dFd
dCyd kinase 0.0436 ± 0.0017 0.0146 ± 0.0033*
Cyd deaminase   1.20 ± 0.10   2.30 ± 0.22*
Ribonucleotide reductase 0.0158 ± 0.00378 0.0370 ± 0.00566*
DNA polymerase 0.0651 ± 0.0042 0.0679 ± 0.0080
Cyd kinase   5.46 ± 0.34   5.50 ± 0.23

Enzyme activities are mean values ± SEM of three individual experiments. *P < 0.01 vs value for MIAPaCa‐2.