Table 5.
Pathological and phenotypic characteristics in 15 Helicobacter pylori‐ and atrophy‐negative patients
| Pathology † | T factor ‡ | MUC5AC | MUC6 | MUC2 | Villin | Cdx2 | Phenotype in parts § | |
|---|---|---|---|---|---|---|---|---|
| Case 1 | sig | se | +++ | ++ | ± | – | ++ | G type |
| Case 2 | por | sm | ++ | + | + | – | + | GI type |
| Case 3 | sig | mp | ++ | ± | – | – | – | G type |
| Case 4 | sig | si | + | – | – | – | ± | G type |
| Case 5 | por | OP (–) | ||||||
| Case 6 | tub2 | ss | ± | ± | – | ± | +++ | N type |
| Case 7 | tub1 | m | – | – | – | – | – | N type |
| Case 8 | tub2 | OP (–) | ||||||
| Case 9 | sig | sm | ++ | – | ++ | ± | +++ | GI type |
| Case 10 | muc | ss | ++ | + | ++ | – | ++ | GI type |
| Case 11 | sig | sm | ++ | + | + | – | ++ | GI type |
| Case 12 | muc | sm | ++ | ++ | ++ | – | + | I type |
| Case 13 | tub2 | m | ++ | ++ | – | ++ | +++ | GI type |
| Case 14 | tub2 | ss | ± | – | + | + | +++ | I type |
| Case 15 | sig | si | + | ± | ± | – | – | G type |
tub1 and tub2 indicate well differentiated‐type and por, muc and sig indicate poorly differentiated‐type gastric cancer according to the Japanese Classification of Gastric Carcinoma.
Depth of invasion indicate mucosa (m), submucosa (sm), muscularis propria (mp), subserosa (ss), serosa‐exposed (se), si (serosa‐infiltrating) and OP (–) indicating no operation.
+Cases with more than 10% of the section area consisting of at least one gastric or intestinal epithelial cell phenotype were classified as gastric (G type) or intestinal (I type) phenotype cancer, respectively. Other cases were classified as either the gastric or intestinal mixed phenotype (GI type), while those with no expression phenotype were grouped as unclassified (N type).