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. 2008 Aug 14;99(8):1528–1538. doi: 10.1111/j.1349-7006.2008.00878.x

Figure 1.

Figure 1

Complex molecular mechanisms of transcriptional regulation of human telomerase reverse transcriptase (hTERT). Representative transcription factors and their upstream factors essential for hTERT regulation are shown in the upper panel. The sites on the promoter are not precisely in scale. +1 indicates the start site of transcription.( 13 ) The proposed model of chromatin remodeling for the regulation of hTERT promoter is shown in the lower panel. Me, methylation of histone; Ac, acetylation of histone.