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Schematic DNA structures of telomerase‐specific oncolytic viruses. Telomelysin (OBP‐301) has E1A and E1B genes linked with an IRES, driven by the human telomerase reverse transcriptase (hTERT) promoter. A variant of OBP‐301 was constructed that has the green fluorescent protein (GFP) gene at the E3 region driven by CMV promoter (OBP‐401). Another variant (OBP‐405) has a mutant fiber containing the RGD peptide in the HI loop of the fiber knob.
