Table 2.
Comparison of Hodgkin lymphoma subtypes and Epstein–Barr virus (EBV) association over time in Taiwan and in previous studies from Western countries
| Subtype | Taiwan, 1982–1995 | Taiwan, 1996–2007 | Studies from Western countries | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % | EBER+ (%) | M/F | Mean age (years) | % | EBER+ (%) | M/F | Mean age (years) | P‐value* | % | EBER+ (%) | M/F | Mean age (years) | Reference | |
| Nodular lymphocyte predominance | 8 | 17 | 4/2 | 55.0 | 6 | 0 | 5/1 | 50.8 | 0.60 | 5 | 0 | MP | 30–50 | ( 17 ) |
| Nodular sclerosis | 53 | 59 | 29/10 | 42.4 | 68 | 40 | 39/28 | 36.6 | 0.045 | 70 | 10–40 | 1/1 | 28 | ( 6, 8, 17 ) |
| Mixed cellularity | 35 | 62 | 20/6 | 36.8 | 13 | 85 | 12/1 | 48.2 | <0.001 | 20–25 | 75 (72–85%) | 7/3 | 37 | ( 6, 8, 17 ) |
| Lymphocyte‐rich classical | 1 | 0 | 0/1 | 32.0 | 6 | 33 | 3/3 | 56.7 | 0.12 | 5 | 57 | 7/3 | >40–50 | ( 17, 33 ) |
| Lymphocyte depletion | 3 | 100 | 2/0 | 64.0 | 2 | 0 | 2/0 | 25.0 | 0.77 | <5 | 12–50 | 3/1 | 37 | ( 8, 17, 32 ) |
| Unclassified | 0 | – | – | – | 5 | 80 | 5/0 | 62.6 | – | 4 | 33–100 | NA | NA | ( 6, 8 ) |
| Total | 57 | 55/19 | 41.9 | 44 | 66/33 | 41.3 | 0.004 | 30–50 | ( 20 ) | |||||
*
P‐value for difference in each subtype frequency in Taiwan. EBER, EBV‐encoded early RNA; M/F, male‐to‐female ratio; MP, male predominance; NA, not available.