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Increased expression of GnT‐V in epithelial cells results in a loss of contact inhibition and increased cell motility. Overexpression of GnT‐III resulted in resistance of E‐cadherin to proteolysis, and the E‐cadherin remained on the cell–cell borders. Conversely, GnT‐III can be up‐regulated through cell–cell interactions; therefore, signals responsible for the maintenance of the cell differentiation phenotype may be neutralized.
