Table 2.
Topological controls used to test the field effect of PCDH10 methylation
| ID | Primary cancer | Topological control specimens | ||||
|---|---|---|---|---|---|---|
| Diagnosis | Site | Methylation | Procured site | Type | Methylation | |
| 052028 | SCC of cervix, stage 2a | Cervix | Positive | Vagina | MC | Negative |
| 062037 | SCC of cervix, stage 4b | Cervix | Positive † | Vagina | MC | Positive |
| 062020 | Adenocarcinoma of cervix, stage 2a | Cervix | Positive | Pelvic LN | MC | Positive |
| 062043 | SCC of cervix, stage 3a at least | Cervix | Negative † | Vagina | MC | Positive |
| 062049 | Recurrent SCC of cervix, with lymph node metastasis | Cervix | N/A | Common iliac LN | MC | Positive |
| 052014 | SCC of cervix, stage 2a | Cervix | Positive | Cervix | NNC | Positive |
| 052028 | SCC of cervix, stage 2a | Cervix | Positive | Cervix | NNC | Positive |
| Vagina | NNC | Positive | ||||
| 062011 | SCC of cervix, stage 2a | Cervix | Positive | Cervix | NNC | Positive |
| 062045 | SCC of cervix, stage 2a | Cervix | Positive | Cervix | NNC | Positive |
| Vagina | NNC | Positive | ||||
| 072052 | SCC of cervix, stage 1b | Cervix | Positive | Cervix | NNC | Positive |
| 072094 | SCC of cervix, stage 1b2 | Cervix | Positive | Cervix | NNC | Positive |
| Stroma under SCC | NNC | Positive | ||||
| 062048 | SCC of cervix, stage 2a | Cervix | Positive | Cervix | NNC | Negative |
| 072058 | Adenocarcinoma of cervix, stage 1b | Cervix | Positive | Cervix | NNC | Negative |
| 082012 | Villoglandular adenocarcinoma of endocervix | Cervix | Negative † | Cervix | NNC | Negative |
| 072081 | CIS of cervix | Cervix | Negative † | Cervix | NNC | Positive |
| 082016 | CIS of cervix | Cervix | Negative † | Cervix | NNC | Negative |
| 082071 | Poorly differentiated adenosquamous Ca of cervix, stage 1b1 | Cervix | Negative | Vagina | NNC | Negative |
| 082085 | SCC of cervix, stage 1a | Cervix | Negative | Cervix | NNC | Negative |
| 062063 | Adenocarcinoma of endometrium, stage 3c | Endometrium | Positive | Cervix | NC | Negative |
| 062072 | Adenocarcinoma of endometrium, stage 1b | Endometrium | Negative | Cervix | NC | Negative |
| 062091 | Endometroid Ca of oviduct, stage 2 | Fallopian tube | Negative | Cervix | NC | Negative |
| 072098 | Adenocarcinoma of endometrium, stage 1a | Endometrium | Negative | Cervix | NC | Negative |
| 082031 | Adenocarcinoma of endometrium, stage 1a | Endometrium | Negative | Cervix | NC | Negative |
| 082069 | Serous cyst adenocarcinoma of ovary, stabe 3c | Ovary | Negative | Cervix | NC | Negative |
| 062048 | SCC of cervix, stage 2a | Cervix | Positive | Endometrium | NCx | Positive |
| 072094 | SCC of cervix, stage 1b2 | Cervix | Positive | Ovary | NCx | Negative |
| Pelvic LN | NCx | Negative | ||||
| 082001 | Adenocarcinoma of cervix, stage 1b2 | Cervix | Negative | Common iliac LN | NCx | Negative |
| 082012 | Villoglandular adenocarcinoma of endocervix | Cervix | Negative † | Endometrium | NCx | Negative |
| 082016 | CIS of cervix | Cervix | Negative † | Endometrium | NCx | Negative |
| 082065 | Neuroendocrine differentiated carcinoma of cervix, stage 4b | Cervix | Negative | Vagina | NCx | Negative |
| Uterus | NCx | Negative | ||||
†
Data were collected from swab specimens. Ca, carcinoma; LN, lymph node; MC, metastatic cancer; N/A, not available; NC, normal cervix from cancer patient; NCx, non‐cervical tissue from cervical cancer patient; NNC, normal tissue next to cancer; SCC, squamous cell carcinoma.