Table 3.
Clinicopathological characteristics of the small‐cell variant of mantle cell lymphoma compared with those of classical and aggressive mantle cell lymphoma
| Small‐MCL | Classical MCL | Aggressive MCL | P value (small vs classical) | |
|---|---|---|---|---|
| Total no. patients | 15 | 151 | 44 | |
| Age | 64.47 ± 9.53 | 66.04 ± 20.82 | 68.11 ± 20.28 | 0.564 |
| Sex (n) | 15 | 151 | 44 | 0.7205 |
| Male | 12 | 126 | 32 | |
| Female | 3 | 25 | 12 | |
| IPI score (n) | 15 | 106 | 36 | 0.1045 |
| High/high–intermediate | 10 (67) | 46 (43) | 27 (75) | |
| Lymphadenopathy (n) | 15 | 151 | 44 | 0.2621 |
| No | 7 (47) | 34 (23) | 1 (2) | |
| Hepatomegaly (n) | 15 | 117 | 39 | 0.0563 |
| Yes | 4 (27) | 11 (9) | 11 (28) | |
| Splenomegaly (n) | 15 | 117 | 39 | <0.0001 |
| Yes | 12 (80) | 32 (27) | 20 (51) | |
| BM involvement (n) | 15 | 114 | 34 | 0.0443 |
| Yes | 12 (80) | 53 (47) | 19 (56) | |
| Leukemic change (n) | 5 | 117 | 41 | 0.1245 |
| Yes | 7 (47) | 33 (28) | 17 (42) | |
| Gut involvement (n) | 12 | 99 | 34 | 1 |
| Yes | 7 (47) | 43 (43) | 8 (24) | |
| Growth pattern (n) | 13 | 136 | 42 | 1 |
| Diffuse | 10 (77) | 48 (35) | 38 (91) | |
| Mantle zone | 3 (23) | 18 (13) | 0 (0) | |
| Ki‐67‐index | ||||
| n | 12 | 103 | 30 | <0.0001 |
| Mean ± 2 SD | 12.5 ± 17.3 | 25.2 ± 25.5 | 73.7 ± 28.9 | |
| CCND1‐index | ||||
| n | 15 | 149 | 44 | 0.2445 |
| Mean ± 2 SD | 53.1 ± 30.4 | 58.1 ± 36.7 | 80.1 ± 27.8 | |
Data are shown as the mean ± 2 SD or the number of patients in each group, with percentages in parentheses, as appropriate. MCL, mantle cell lymphoma; IPI, International Prognostic Index; CCND1, cyclin D1.