Figure 3.

Histological features of glypican 3 (GPC3)‐expressing gastric carcinoma (GC). (a–d) Characteristic histological patterns in glypican 3 (GPC3)‐expressing gastric carcinoma (GC). (a) Hepatoid pattern showing sheet‐like proliferation of polygonal tumor cells with abundant eosinophilic cytoplasm (hematoxylin–eosin [HE], ×200). (b) Clear‐cell pattern showing papillary proliferation bearing a close resemblance to ovarian clear‐cell adenocarcinoma (HE, ×200). (c) Solid area of clear‐cell pattern composed of a sheet of polygonal clear cells (HE, ×200). (d) Fetal gut‐like appearance of clear‐cell pattern showing a tubulopapillary structure lined by clear columnar cells with relatively mild cytological atypia (HE, ×200). (e) Eosinophilic material in the luminal structure and (f) intracytoplasmic hyaline globules in GPC3‐expressing GC (HE, ×400). These materials often showed positive staining for GPC3.