. 2006 Aug 1;97(11):1129–1138. doi: 10.1111/j.1349-7006.2006.00290.x

Table 3.

Polymorphisms reported in association with gastric cancer risk: only significant associations are with odds ratio (OR) and 95% confidence interval (95%CI)

Polymorphism	Country	OR (95%CI)
ACE I/D	Germany⁽ ¹²³ ⁾	DD, DI:0.55 (0.31–0.96), II:0.20 (0.08–0.54)
Cyclin D1 G870A	Germany⁽ ¹²⁴ ⁾	Significant association (P = 0.003)
CYP1A1 Ile/Val	China⁽ ¹²⁵ ⁾	IleIle, ValVal:4.84 (1.24–22.07)
CYP2C6 1/4	Japan⁽ ¹²⁶ ⁾	11/14, 44 : 3.14 (1.05–9.41)
CYP2C19 1/2/*3	Japan⁽ ¹²⁷ ⁾	11, no*1:1.98 (1.07–3.65)
CYP2E1 RsaI	Japan ^†
	Brazil ^†
	China⁽ ¹²⁸ ⁾
E‐cadherin C‐160^a	Taiwan⁽ ¹²⁹ ⁾	CC, AA:0.20 (0.06–0.56)
EGF A61G	Japan⁽ ¹³⁰ ⁾
GSTM1 present/null	UK ^†	Present, null:2.9 (1.25–6.73)
	Japan ^†	Present, null:1.70 (1.05–2.8)
	Iran ^†	Present, null:2.3 (1.15–4.95)
	Poland ^†
	China⁽ ¹²⁵ ⁾	Present, null:2.81 (1.39–5.71)
	Taiwan⁽ ¹³¹ ⁾	Present, null:1.75 (1.04–2.96)
GSTM3 IVS6del3	Poland ^†
GSTP1 I105V	Japan ^†
GSTP1 I105V	Poland ^†
GSTT1 present/null	China ^†	Present, null:2.5 (1.01–6.2)
	Poland ^†	Present, null:3.1 (1.5–6.5) among current smokers
	Japan ^†
IL‐1B C‐1473G	Korea⁽ ¹³¹ ⁾
C‐511T	Poland⁽ ⁶³ ⁾	CC, CT:1.8 (1.3–2.4), TT:2.6 (1.7–3.9)
	Portugal ^†	CC, CT/TT:1.7 (1.1–2.7)
	Taiwan⁽ ¹¹⁶ ⁾
C3954T	Poland⁽ ⁶³ ⁾
IL‐1RN 86‐bp VNTR	Poland⁽ ⁶³ ⁾	4rpt4rpt, 2rp2rp:3.7 (2.4–5.7)
IL‐1RN 86‐bp VNTR	Taiwan⁽ ¹¹⁶ ⁾
IL‐1B C‐511T +IL‐1RN 86‐bp VNTR	Portugal ^†	CC + LL/L2rpt, CT/TT+2rpt2rp:9.0 (3.5–23.0)
IL‐2 G‐384T, G114T	China⁽ ¹³³ ⁾
IL‐4 C‐590T	Taiwan⁽ ¹¹⁶ , ¹³⁴ ⁾
RP1/RP2	Taiwan⁽ ¹³⁴ ⁾
IL‐4R Ile50Val	Taiwan⁽ ¹¹⁶ ⁾
Gln576Arg	Taiwan⁽ ¹¹⁶ ⁾
IL‐10 G‐1082A	Taiwan⁽ ¹¹⁶ ⁾	AA, AG:2.14 (1.07–4.30)
IL‐10 G‐1082A	China⁽ ¹³³ ⁾
T‐819C	Taiwan⁽ ¹¹⁶ ⁾	TT, TC:1.83 (1.23–2.71), CC:1.95 (1.03–3.69)
T‐819C	China⁽ ¹³³ ⁾
MK G‐2669A	Taiwan⁽ ¹³⁴ ⁾
MTHFR C677T	China ^†	CC, TT:1.87 (1.00–3.48)
MTHFR C677T	Mexico⁽ ¹³⁵ ⁾	CC, TT:1.62 (1.00–2.59)
C677T, A1298C	Korea⁽ ¹³⁶ ⁾
MUC1 VNTR	Portugal ^†	Large, small: 4.3 (1.8–10.5)
MUC6 VNTR	Portugal ^†	Large, small: P < 0.05
MYCL1(L‐myc) EcoRI	Japan ^†	LL, LS:1.55 (1.03–2.34)
MYCL1(L‐myc) EcoRI	Japan ^†	LL, LS/SS:3.09 (1.33–7.21)
NAT1	UK ^†	Slow, rapid:2.6 (1.3–5.3)
NAT1	Japan ^†
NAT2	UK ^†
NAT2	Japan ^†
NQO1 C609T	Japan⁽ ¹³⁷ ⁾
OGG1 Ser327Cys	Japan ^†
OGG1 Ser327Cys	Brazil ^†
p16 ^INK4A C540G	Germany⁽ ¹²⁴ ⁾
C570G	Taiwan⁽ ¹³⁴ ⁾
p21 codon31	Taiwan⁽ ¹³⁴ ⁾
p53 codon72	Taiwan⁽ ¹³⁴ ⁾	Significant association (P = 0.02)
PPAR Pro12Ala(C/G)	China⁽ ⁵⁶ ⁾	CC, CG/GG:2.5 (1.1–5.8)
TFF2 VNTR	Portugal ^†
TNF‐A G‐308A	Korea ^†
TNF‐A G‐308A	Taiwan⁽ ¹¹⁶ ⁾
G‐238A	Korea ^†
G‐238A	Taiwan⁽ ¹¹⁶ ⁾
XRCC1 Arg194Trp	Brazil⁽ ¹³⁸ ⁾
Arg399Gln	Brazil⁽ ¹³⁸ ⁾
Arg194Trp + Arg399Gln	China ^†	TrpTrp + ArgArg, ArgArg + ArgGln/GlnGln:1.73 (1.12–2.69)
XRCC3 Thr241Met	Brazil⁽ ¹³⁸ ⁾

^{^†}

Studies cited in the review by Gonzalez et al.⁽ ¹²² ⁾; L, alleles longer than 2rpt.